Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071783423> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2071783423 endingPage "28" @default.
- W2071783423 startingPage "20" @default.
- W2071783423 abstract "The actions of spinosyns on insect γ-aminobutyric acid (GABA) receptor function were assessed with small-diameter neurons from the central nervous system of the American cockroach (Periplaneta americana) by the whole-cell patch-clamp technique. In the absence of adenine nucleotides, neuronal responses to repeated applications of GABA diminished to zero within a matter of minutes. This effect is commonly referred to as rundown and, for these neurons, has previously been shown to be due to the absence of internal adenine nucleotides. Application of insecticidal spinosyns prior to the first application of GABA significantly accelerated the rundown of GABA responses, while noninsecticidal spinosyns had no effect on the rate of GABA response rundown. When GABA response rundown was blocked by the inclusion of adenosine 5′ triphosphate in the recording electrode, spinosyn A, the primary constituent of the novel insecticide spinosad, was found to elicit an irreversible current at concentrations above 1 nM. The electrical and pharmacological properties of this current suggest that it is carried by Cl− ions. Concurrent with the onset of this current, GABA responses were decreased and ultimately diminished to zero. In summary, insecticidal spinosyns have potent effects on the function of the GABA receptors of small-diameter cockroach neurons and can elicit a small-amplitude Cl− current. These findings may have implications toward the insecticidal mechanism of action of spinosyns." @default.
- W2071783423 created "2016-06-24" @default.
- W2071783423 creator A5001250328 @default.
- W2071783423 date "2001-09-01" @default.
- W2071783423 modified "2023-09-30" @default.
- W2071783423 title "Actions of Insecticidal Spinosyns on γ-Aminobutyric Acid Responses from Small-Diameter Cockroach Neurons" @default.
- W2071783423 cites W1981792226 @default.
- W2071783423 cites W2009667219 @default.
- W2071783423 cites W2012518189 @default.
- W2071783423 cites W2057054587 @default.
- W2071783423 cites W2091085927 @default.
- W2071783423 cites W2145242256 @default.
- W2071783423 cites W2484667967 @default.
- W2071783423 doi "https://doi.org/10.1006/pest.2001.2559" @default.
- W2071783423 hasPublicationYear "2001" @default.
- W2071783423 type Work @default.
- W2071783423 sameAs 2071783423 @default.
- W2071783423 citedByCount "131" @default.
- W2071783423 countsByYear W20717834232012 @default.
- W2071783423 countsByYear W20717834232013 @default.
- W2071783423 countsByYear W20717834232014 @default.
- W2071783423 countsByYear W20717834232015 @default.
- W2071783423 countsByYear W20717834232016 @default.
- W2071783423 countsByYear W20717834232017 @default.
- W2071783423 countsByYear W20717834232018 @default.
- W2071783423 countsByYear W20717834232019 @default.
- W2071783423 countsByYear W20717834232020 @default.
- W2071783423 countsByYear W20717834232021 @default.
- W2071783423 countsByYear W20717834232022 @default.
- W2071783423 countsByYear W20717834232023 @default.
- W2071783423 crossrefType "journal-article" @default.
- W2071783423 hasAuthorship W2071783423A5001250328 @default.
- W2071783423 hasConcept C12554922 @default.
- W2071783423 hasConcept C168258287 @default.
- W2071783423 hasConcept C170493617 @default.
- W2071783423 hasConcept C185592680 @default.
- W2071783423 hasConcept C18903297 @default.
- W2071783423 hasConcept C2777346155 @default.
- W2071783423 hasConcept C2777771985 @default.
- W2071783423 hasConcept C2779414652 @default.
- W2071783423 hasConcept C2779808186 @default.
- W2071783423 hasConcept C2780625307 @default.
- W2071783423 hasConcept C55493867 @default.
- W2071783423 hasConcept C86803240 @default.
- W2071783423 hasConcept C98274493 @default.
- W2071783423 hasConceptScore W2071783423C12554922 @default.
- W2071783423 hasConceptScore W2071783423C168258287 @default.
- W2071783423 hasConceptScore W2071783423C170493617 @default.
- W2071783423 hasConceptScore W2071783423C185592680 @default.
- W2071783423 hasConceptScore W2071783423C18903297 @default.
- W2071783423 hasConceptScore W2071783423C2777346155 @default.
- W2071783423 hasConceptScore W2071783423C2777771985 @default.
- W2071783423 hasConceptScore W2071783423C2779414652 @default.
- W2071783423 hasConceptScore W2071783423C2779808186 @default.
- W2071783423 hasConceptScore W2071783423C2780625307 @default.
- W2071783423 hasConceptScore W2071783423C55493867 @default.
- W2071783423 hasConceptScore W2071783423C86803240 @default.
- W2071783423 hasConceptScore W2071783423C98274493 @default.
- W2071783423 hasIssue "1" @default.
- W2071783423 hasLocation W20717834231 @default.
- W2071783423 hasOpenAccess W2071783423 @default.
- W2071783423 hasPrimaryLocation W20717834231 @default.
- W2071783423 hasRelatedWork W1999642517 @default.
- W2071783423 hasRelatedWork W2062913193 @default.
- W2071783423 hasRelatedWork W2063092034 @default.
- W2071783423 hasRelatedWork W2068162689 @default.
- W2071783423 hasRelatedWork W2071783423 @default.
- W2071783423 hasRelatedWork W2084506165 @default.
- W2071783423 hasRelatedWork W2120717370 @default.
- W2071783423 hasRelatedWork W2183638937 @default.
- W2071783423 hasRelatedWork W257760021 @default.
- W2071783423 hasRelatedWork W2816302827 @default.
- W2071783423 hasVolume "71" @default.
- W2071783423 isParatext "false" @default.
- W2071783423 isRetracted "false" @default.
- W2071783423 magId "2071783423" @default.
- W2071783423 workType "article" @default.