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- W2071785694 abstract "Magnetic resonance guided focused ultrasound surgery (MRgFUS) is an emerging technology that can non-invasivelyheat and ablate targeted tissue utilizing ultrasound energy. Use of MR imaging for treatment guidance provides severalkey advantages over more widely used ultrasound guidance for focused ultrasound ablation. MR allows for precisetargeting, detailed beam path visualization, real time non-invasive temperature measurement, and treatment feedback toensure therapeutic goals are achieved. In the realm of oncology, management of painful bone metastases is a commonand daunting clinical problem. The Insightec ExAblate System has been shown in phase I/II trials for treatment of bonemetastases to have an excellent safety profile and high rates of pain response. An international multi-center phase IIItrial for patients with painful bone metastases or multiple myeloma who are not candidates for radiation therapy iscurrently open. Patients are randomized 3:1 to MRgFUS or sham treatment with crossover to study treatment allowedfor sham failures. The primary study endpoint is assessment of pain control over 3 months following treatment. Inaddition safety, quality of life, cost effectiveness analysis, and patient perceived clinical benefit are also being assessed.Details of the MRgFUS system, technical and clinical therapeutic parameters, use of real time non-invasive MRthermometry, and examples of patient treatments with use of MRgFUS to treat bone metastases will be discussed. Newdirections in use of MRgFUS including an update on development of a new mobile applicator and integration ofMRgFUS in multimodality oncologic care will also be presented." @default.
- W2071785694 created "2016-06-24" @default.
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- W2071785694 date "2011-02-10" @default.
- W2071785694 modified "2023-10-18" @default.
- W2071785694 title "Magnetic resonance-guided focused ultrasound surgery for treatment of painful osseous metastases" @default.
- W2071785694 doi "https://doi.org/10.1117/12.876434" @default.
- W2071785694 hasPublicationYear "2011" @default.
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