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• W2071787927 abstract "Electrophysiological studies of the effects of morphine and naloxone on the sensory input to the caudate nucleus, substantia nigra, hypothalamus, and pineal body in freely behaving rats were performed. The averaged sensory evoked responses were recorded simultaneously in the four structures with permanent semimicroelectrodes (60-μm diameter) implanted stereotaxically 6 to 8 days before experiments were begun. After control rcordings were taken, a group of animals was injected intraperitoneally with 10 or 50 mg/kg of morphine and recordings were resumed for 45 min. Naloxone (1 mg/kg) was then administered, and recordings were again resumed for a period of 45 min. A separate group of animals was injected only with naloxone (1 mg/kg). Three consistent components of the averaged sensory evoked potentials were evaluated. Some evoked response amplitudes were increased, some were decreased, and, in several cases, morphine induced no alteration. Each structure responded differently to morphine treatment. Naloxone partially reversed the morphine effects, but, when given alone, often itself produced alterations of the evoked potentials. The predominant alteration was a decrease in response amplitudes. The duration of morphine effects was considerably longer than the duration of naloxone. Each structure examined in the present study responded differently to naloxone. The possible mechanisms of naloxone actions could include blockade of an endogenous morphine-like substance." @default.
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• W2071787927 date "1976-12-01" @default.
• W2071787927 modified "2023-09-24" @default.
• W2071787927 title "Opiate-independent effects of naloxone on the central nervous system—Neurophysiological approach" @default.
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• W2071787927 doi "https://doi.org/10.1016/0014-4886(76)90144-8" @default.
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