Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071788052> ?p ?o ?g. }
- W2071788052 endingPage "8" @default.
- W2071788052 startingPage "1" @default.
- W2071788052 abstract "Microinjection of drugs, such as muscimol, into the substantia nigra pars reticulata (SNpr) can inhibit several types of experimental seizures. Some findings suggested that this was a result of disinhibition of neurons receiving input from GAB Aergic nigrotectal cells. Indeed, it was reported that bicuculline methiodide (BMI), infused into the tectal region that was reported to receive nigral input, produced an anticonvulsant effect against maximal electroshock (MES) convulsion. Since previous work had suggested that the anticonvulsant effect of intranigral muscimol depended on the particular experimental seizure used, three different experimental seizures were used in the present study to evaluate the effects of BMI infusion into the tectum. Guide cannulas aimed at the tectal region receiving nigral innervation were stereotaxically implanted in rats a week before testing. Bilateral intratectal infusions of BMI (25 ng/ side) had an anticonvulsant effect against MES convulsions, confirming a previous report. In contrast, the same BMI pretreatment worsened convulsions produced by either systemic pentylenetetrazol (40 mg/kg i.p.) or bicuculline (0.5 mg/kg i.V.). The effects of intratectal BMI were seizure model-dependent, suggesting different functional interconnections between tectum and those pathways responsible for generalization of MES as compared to PTZ or bicuculline convulsions." @default.
- W2071788052 created "2016-06-24" @default.
- W2071788052 creator A5010843715 @default.
- W2071788052 creator A5045289644 @default.
- W2071788052 date "1992-06-01" @default.
- W2071788052 modified "2023-10-11" @default.
- W2071788052 title "Infusion of bicuculline methiodide into the tectum: model specificity of pro- and anticonvulsant actions" @default.
- W2071788052 cites W1966511690 @default.
- W2071788052 cites W1988410829 @default.
- W2071788052 cites W1988475773 @default.
- W2071788052 cites W1989100070 @default.
- W2071788052 cites W2001784546 @default.
- W2071788052 cites W2007783018 @default.
- W2071788052 cites W2010421890 @default.
- W2071788052 cites W2017830531 @default.
- W2071788052 cites W2019962468 @default.
- W2071788052 cites W2021782673 @default.
- W2071788052 cites W2023408817 @default.
- W2071788052 cites W2023642970 @default.
- W2071788052 cites W2024985045 @default.
- W2071788052 cites W2025337851 @default.
- W2071788052 cites W2027642314 @default.
- W2071788052 cites W2031385511 @default.
- W2071788052 cites W2031801634 @default.
- W2071788052 cites W2035538860 @default.
- W2071788052 cites W2038331446 @default.
- W2071788052 cites W2049381848 @default.
- W2071788052 cites W2056353685 @default.
- W2071788052 cites W2062268242 @default.
- W2071788052 cites W2071735714 @default.
- W2071788052 cites W2084676793 @default.
- W2071788052 cites W2092641170 @default.
- W2071788052 cites W2159026414 @default.
- W2071788052 cites W2884454851 @default.
- W2071788052 doi "https://doi.org/10.1016/0920-1211(92)90085-8" @default.
- W2071788052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1526225" @default.
- W2071788052 hasPublicationYear "1992" @default.
- W2071788052 type Work @default.
- W2071788052 sameAs 2071788052 @default.
- W2071788052 citedByCount "17" @default.
- W2071788052 countsByYear W20717880522016 @default.
- W2071788052 countsByYear W20717880522018 @default.
- W2071788052 countsByYear W20717880522020 @default.
- W2071788052 countsByYear W20717880522021 @default.
- W2071788052 crossrefType "journal-article" @default.
- W2071788052 hasAuthorship W2071788052A5010843715 @default.
- W2071788052 hasAuthorship W2071788052A5045289644 @default.
- W2071788052 hasConcept C126322002 @default.
- W2071788052 hasConcept C134018914 @default.
- W2071788052 hasConcept C15744967 @default.
- W2071788052 hasConcept C168258287 @default.
- W2071788052 hasConcept C169760540 @default.
- W2071788052 hasConcept C170493617 @default.
- W2071788052 hasConcept C185592680 @default.
- W2071788052 hasConcept C2775858608 @default.
- W2071788052 hasConcept C2776599063 @default.
- W2071788052 hasConcept C2776819090 @default.
- W2071788052 hasConcept C2777010014 @default.
- W2071788052 hasConcept C2778186239 @default.
- W2071788052 hasConcept C2778938600 @default.
- W2071788052 hasConcept C2779188335 @default.
- W2071788052 hasConcept C2779324764 @default.
- W2071788052 hasConcept C2779994606 @default.
- W2071788052 hasConcept C2780763569 @default.
- W2071788052 hasConcept C42219234 @default.
- W2071788052 hasConcept C55493867 @default.
- W2071788052 hasConcept C71924100 @default.
- W2071788052 hasConcept C98274493 @default.
- W2071788052 hasConceptScore W2071788052C126322002 @default.
- W2071788052 hasConceptScore W2071788052C134018914 @default.
- W2071788052 hasConceptScore W2071788052C15744967 @default.
- W2071788052 hasConceptScore W2071788052C168258287 @default.
- W2071788052 hasConceptScore W2071788052C169760540 @default.
- W2071788052 hasConceptScore W2071788052C170493617 @default.
- W2071788052 hasConceptScore W2071788052C185592680 @default.
- W2071788052 hasConceptScore W2071788052C2775858608 @default.
- W2071788052 hasConceptScore W2071788052C2776599063 @default.
- W2071788052 hasConceptScore W2071788052C2776819090 @default.
- W2071788052 hasConceptScore W2071788052C2777010014 @default.
- W2071788052 hasConceptScore W2071788052C2778186239 @default.
- W2071788052 hasConceptScore W2071788052C2778938600 @default.
- W2071788052 hasConceptScore W2071788052C2779188335 @default.
- W2071788052 hasConceptScore W2071788052C2779324764 @default.
- W2071788052 hasConceptScore W2071788052C2779994606 @default.
- W2071788052 hasConceptScore W2071788052C2780763569 @default.
- W2071788052 hasConceptScore W2071788052C42219234 @default.
- W2071788052 hasConceptScore W2071788052C55493867 @default.
- W2071788052 hasConceptScore W2071788052C71924100 @default.
- W2071788052 hasConceptScore W2071788052C98274493 @default.
- W2071788052 hasIssue "1" @default.
- W2071788052 hasLocation W20717880521 @default.
- W2071788052 hasLocation W20717880522 @default.
- W2071788052 hasOpenAccess W2071788052 @default.
- W2071788052 hasPrimaryLocation W20717880521 @default.
- W2071788052 hasRelatedWork W1935227533 @default.
- W2071788052 hasRelatedWork W2018864972 @default.
- W2071788052 hasRelatedWork W2037606943 @default.
- W2071788052 hasRelatedWork W2064013781 @default.