FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071796997> ?p ?o ?g. }

• W2071796997 endingPage "164" @default.
• W2071796997 startingPage "147" @default.
• W2071796997 abstract "Characterizing deleterious genomic mutations is important. Most of the few current estimates come from the mutation–accumulation (M-A) approach, which has been extremely time- and labour-consuming. There is a resurgent interest in implementing this approach. However, its estimation properties under different experimental designs are poorly understood. By simulations we investigate these issues in detail. We found that many of the previous M-A experiments could have been more efficiently implemented with much less time and expense while still achieving the same estimation accuracy. If more than 100 lines are employed in M-A and if each line is replicated at least 10 times during each assay, an experiment of 10 M-A generations with two assays (at the beginning and at the end of M-A) may achieve at least the same estimation quality as a typical M-A experiment. The number of replicates per M-A line necessary for each assay largely depends on the magnitude of environmental variance. While 10 replicates are reasonable for assaying most fitness traits, many more are needed for viability, which has an exceptionally large environmental variance. The investigation is mainly carried out using Bateman–Mukai's method of moments for estimation. Estimation using Keightley's maximum likelihood is also investigated and discussed. These results should not only be useful for planning efficient M-A experiments, but also may help empiricists in deciding to adopt the M-A approach with manageable labour, time and resources." @default.
• W2071796997 created "2016-06-24" @default.
• W2071796997 creator A5041706927 @default.
• W2071796997 creator A5052883326 @default.
• W2071796997 creator A5086155499 @default.
• W2071796997 date "1999-04-01" @default.
• W2071796997 modified "2023-10-08" @default.
• W2071796997 title "On the experimental design and data analysis of mutation accumulation experiments" @default.
• W2071796997 cites W1518271078 @default.
• W2071796997 cites W1551315794 @default.
• W2071796997 cites W1834846263 @default.
• W2071796997 cites W1877460931 @default.
• W2071796997 cites W1900500601 @default.
• W2071796997 cites W1955170827 @default.
• W2071796997 cites W1958991600 @default.
• W2071796997 cites W1979710821 @default.
• W2071796997 cites W2021956659 @default.
• W2071796997 cites W2022518804 @default.
• W2071796997 cites W2024024857 @default.
• W2071796997 cites W2027662941 @default.
• W2071796997 cites W2029856991 @default.
• W2071796997 cites W2033290951 @default.
• W2071796997 cites W2040560871 @default.
• W2071796997 cites W2045716211 @default.
• W2071796997 cites W2105621710 @default.
• W2071796997 cites W2106962907 @default.
• W2071796997 cites W2139043858 @default.
• W2071796997 cites W2167243456 @default.
• W2071796997 cites W2170687500 @default.
• W2071796997 cites W2332599861 @default.
• W2071796997 doi "https://doi.org/10.1017/s0016672398003681" @default.
• W2071796997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10341667" @default.
• W2071796997 hasPublicationYear "1999" @default.
• W2071796997 type Work @default.
• W2071796997 sameAs 2071796997 @default.
• W2071796997 citedByCount "14" @default.
• W2071796997 crossrefType "journal-article" @default.
• W2071796997 hasAuthorship W2071796997A5041706927 @default.
• W2071796997 hasAuthorship W2071796997A5052883326 @default.
• W2071796997 hasAuthorship W2071796997A5086155499 @default.
• W2071796997 hasBestOaLocation W20717969971 @default.
• W2071796997 hasConcept C104317684 @default.
• W2071796997 hasConcept C105795698 @default.
• W2071796997 hasConcept C121332964 @default.
• W2071796997 hasConcept C121955636 @default.
• W2071796997 hasConcept C149782125 @default.
• W2071796997 hasConcept C162324750 @default.
• W2071796997 hasConcept C187736073 @default.
• W2071796997 hasConcept C196083921 @default.
• W2071796997 hasConcept C198352243 @default.
• W2071796997 hasConcept C2524010 @default.
• W2071796997 hasConcept C2779530757 @default.
• W2071796997 hasConcept C33923547 @default.
• W2071796997 hasConcept C34559072 @default.
• W2071796997 hasConcept C41008148 @default.
• W2071796997 hasConcept C501734568 @default.
• W2071796997 hasConcept C54355233 @default.
• W2071796997 hasConcept C62520636 @default.
• W2071796997 hasConcept C86803240 @default.
• W2071796997 hasConcept C96250715 @default.
• W2071796997 hasConceptScore W2071796997C104317684 @default.
• W2071796997 hasConceptScore W2071796997C105795698 @default.
• W2071796997 hasConceptScore W2071796997C121332964 @default.
• W2071796997 hasConceptScore W2071796997C121955636 @default.
• W2071796997 hasConceptScore W2071796997C149782125 @default.
• W2071796997 hasConceptScore W2071796997C162324750 @default.
• W2071796997 hasConceptScore W2071796997C187736073 @default.
• W2071796997 hasConceptScore W2071796997C196083921 @default.
• W2071796997 hasConceptScore W2071796997C198352243 @default.
• W2071796997 hasConceptScore W2071796997C2524010 @default.
• W2071796997 hasConceptScore W2071796997C2779530757 @default.
• W2071796997 hasConceptScore W2071796997C33923547 @default.
• W2071796997 hasConceptScore W2071796997C34559072 @default.
• W2071796997 hasConceptScore W2071796997C41008148 @default.
• W2071796997 hasConceptScore W2071796997C501734568 @default.
• W2071796997 hasConceptScore W2071796997C54355233 @default.
• W2071796997 hasConceptScore W2071796997C62520636 @default.
• W2071796997 hasConceptScore W2071796997C86803240 @default.
• W2071796997 hasConceptScore W2071796997C96250715 @default.
• W2071796997 hasIssue "2" @default.
• W2071796997 hasLocation W20717969971 @default.
• W2071796997 hasLocation W20717969972 @default.
• W2071796997 hasOpenAccess W2071796997 @default.
• W2071796997 hasPrimaryLocation W20717969971 @default.
• W2071796997 hasRelatedWork W1717631657 @default.
• W2071796997 hasRelatedWork W2020398766 @default.
• W2071796997 hasRelatedWork W2061430950 @default.
• W2071796997 hasRelatedWork W2119158312 @default.
• W2071796997 hasRelatedWork W2132234215 @default.
• W2071796997 hasRelatedWork W2383206121 @default.
• W2071796997 hasRelatedWork W2416610374 @default.
• W2071796997 hasRelatedWork W2552050053 @default.
• W2071796997 hasRelatedWork W4251389202 @default.
• W2071796997 hasRelatedWork W4283273863 @default.
• W2071796997 hasVolume "73" @default.
• W2071796997 isParatext "false" @default.
• W2071796997 isRetracted "false" @default.
• W2071796997 magId "2071796997" @default.

• next