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- W2071799062 abstract "Hematopoietic stem cells (HSCs) give rise to all blood lineages. The fact that transcription factors (TFs) determine gene expression profiles during hematopoiesis has been broadly demonstrated. However, we still lack a detailed understanding about how the chromatin context influences the ability of TFs in activating or repressing genes. Because chromatin modifications might play significant roles for TF binding and function, we investigate the importance of H3K9me3, a repressive chromatin mark established by the histone methyltransferase Setdb1." @default.
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- W2071799062 date "2013-08-01" @default.
- W2071799062 modified "2023-10-14" @default.
- W2071799062 title "Deletion of the histone methyltransferase Setdb1 during hematopoiesis results in hematopoietic stem cell failure and abrogates B cell development" @default.
- W2071799062 doi "https://doi.org/10.1016/j.exphem.2013.05.072" @default.
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