FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071806278> ?p ?o ?g. }

• W2071806278 endingPage "2146" @default.
• W2071806278 startingPage "2138" @default.
• W2071806278 abstract "Polymorphonuclear neutrophils (PMNs) express the high and low affinity receptors to formylated peptides (mFPR1 and mFPR2 in mice, accordingly). RhoA/ROCK (Rho activated kinase) pathway is crucial for cell motility and oxidase activity regulated via FPRs. There are contradictory data on RhoA-mediated regulation of NADPH oxidase activity in phagocytes. We have shown divergent Rho GTPases signaling via mFPR1 and mFPR2 to NADPH oxidase in PMNs from inflammatory site. The present study was aimed to find out the role of RhoA/ROCK in the respiratory burst activated via mFPR1 and mFPR2 in the bone marrow PMNs. Different kinetics of RhoA activation were detected with 0.1μM fMLF and 1μM WKYMVM operating via mFPR1 and mFPR2, accordingly. RhoA was translocated in fMLF-activated cells towards the cell center and juxtamembrane space versus uniform allocation in the resting cells. Specific inhibition of RhoA by CT04, Rho inhibitor I, weakly depressed the respiratory burst induced via mFPR1, but significantly increased the one induced via mFPR2. Inhibition of ROCK, the main effector of RhoA, by Y27632 led to the same effect on the respiratory burst. Regulation of mFPR2-induced respiratory response by ROCK was impossible under the cytoskeleton disruption by cytochalasin D, whereas it persisted in the case of mFPR1 activation. Thus we suggest RhoA to be one of the regulatory and signal transduction components in the respiratory burst through FPRs in the mouse bone marrow PMNs. Both mFPR1 and mFPR2 binding with a ligand trigger the activation of RhoA. FPR1 signaling through RhoA/ROCK increases NADPH-oxidase activity. But in FPR2 action RhoA/ROCK together with cytoskeleton-linked systems down-regulates NADPH-oxidase. This mechanism could restrain the reactive oxygen species dependent damage of own tissues during the chemotaxis of PMNs and in the resting cells." @default.
• W2071806278 created "2016-06-24" @default.
• W2071806278 creator A5022154940 @default.
• W2071806278 creator A5034060844 @default.
• W2071806278 creator A5064977312 @default.
• W2071806278 date "2014-10-01" @default.
• W2071806278 modified "2023-10-12" @default.
• W2071806278 title "RhoA/ROCK downregulates FPR2-mediated NADPH oxidase activation in mouse bone marrow granulocytes" @default.
• W2071806278 cites W1175152041 @default.
• W2071806278 cites W1506821425 @default.
• W2071806278 cites W1548728050 @default.
• W2071806278 cites W1558468202 @default.
• W2071806278 cites W1576411973 @default.
• W2071806278 cites W1583083707 @default.
• W2071806278 cites W1634549591 @default.
• W2071806278 cites W1910332340 @default.
• W2071806278 cites W191068967 @default.
• W2071806278 cites W1948361600 @default.
• W2071806278 cites W1970330995 @default.
• W2071806278 cites W1971117764 @default.
• W2071806278 cites W1972507748 @default.
• W2071806278 cites W1973386259 @default.
• W2071806278 cites W1973628719 @default.
• W2071806278 cites W1974713792 @default.
• W2071806278 cites W1983443986 @default.
• W2071806278 cites W1987508105 @default.
• W2071806278 cites W1988215618 @default.
• W2071806278 cites W1990163802 @default.
• W2071806278 cites W1990621187 @default.
• W2071806278 cites W1990956893 @default.
• W2071806278 cites W1991887088 @default.
• W2071806278 cites W1993980819 @default.
• W2071806278 cites W1995699249 @default.
• W2071806278 cites W1996733845 @default.
• W2071806278 cites W2001328992 @default.
• W2071806278 cites W2002776682 @default.
• W2071806278 cites W2003732215 @default.
• W2071806278 cites W2005020760 @default.
• W2071806278 cites W2007596877 @default.
• W2071806278 cites W2008235088 @default.
• W2071806278 cites W2010307209 @default.
• W2071806278 cites W2013773138 @default.
• W2071806278 cites W2014813847 @default.
• W2071806278 cites W2015081253 @default.
• W2071806278 cites W2016563044 @default.
• W2071806278 cites W2036359942 @default.
• W2071806278 cites W2037654515 @default.
• W2071806278 cites W2038731722 @default.
• W2071806278 cites W2041259216 @default.
• W2071806278 cites W2042209974 @default.
• W2071806278 cites W2046515539 @default.
• W2071806278 cites W2048635536 @default.
• W2071806278 cites W2052996144 @default.
• W2071806278 cites W2053146787 @default.
• W2071806278 cites W2057320974 @default.
• W2071806278 cites W2057729428 @default.
• W2071806278 cites W2064253903 @default.
• W2071806278 cites W2064634578 @default.
• W2071806278 cites W2064843753 @default.
• W2071806278 cites W2064925178 @default.
• W2071806278 cites W2066871278 @default.
• W2071806278 cites W2071657221 @default.
• W2071806278 cites W2080218434 @default.
• W2071806278 cites W2084009414 @default.
• W2071806278 cites W2086487052 @default.
• W2071806278 cites W2090739732 @default.
• W2071806278 cites W2093597913 @default.
• W2071806278 cites W2102312968 @default.
• W2071806278 cites W2103067652 @default.
• W2071806278 cites W2117985944 @default.
• W2071806278 cites W2118217258 @default.
• W2071806278 cites W2125563801 @default.
• W2071806278 cites W2125762027 @default.
• W2071806278 cites W2128250758 @default.
• W2071806278 cites W2130172628 @default.
• W2071806278 cites W2131896212 @default.
• W2071806278 cites W2136682979 @default.
• W2071806278 cites W2145357604 @default.
• W2071806278 cites W2145681094 @default.
• W2071806278 cites W2152462284 @default.
• W2071806278 cites W2157537726 @default.
• W2071806278 cites W2157721575 @default.
• W2071806278 cites W2165803049 @default.
• W2071806278 cites W2166650590 @default.
• W2071806278 cites W2188522718 @default.
• W2071806278 cites W2432891023 @default.
• W2071806278 cites W4230157505 @default.
• W2071806278 doi "https://doi.org/10.1016/j.cellsig.2014.05.017" @default.
• W2071806278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24880063" @default.
• W2071806278 hasPublicationYear "2014" @default.
• W2071806278 type Work @default.
• W2071806278 sameAs 2071806278 @default.
• W2071806278 citedByCount "21" @default.
• W2071806278 countsByYear W20718062782014 @default.
• W2071806278 countsByYear W20718062782016 @default.
• W2071806278 countsByYear W20718062782017 @default.
• W2071806278 countsByYear W20718062782018 @default.
• W2071806278 countsByYear W20718062782019 @default.

• next