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• W2071808146 abstract "Introduction The coagulation activation in β-thalassaemia is multifactorial and most likely a consequence of the exposure of phosphatidylserine (PS) on RBCs surface. The degree of PS exposure and procoagulant activity of RBCs in β-thalassaemia trait (BTT) subjects carrying common Mediterranean mutations were assessed. Methods Eighty BTT subjects carrying common Mediterranean mutations (β+, n = 53 and β0, n = 27) and sixty healthy subjects served as controls were studied. Plasma prothrombin fragment 1+2 (F1+2), percentage of PS expression on RBCs membrane, clotting times of modified thromboplastin generation test (MTGT) and modified partial thromboplastin with kaolin (MPTTK) were estimated. Results The percentage of annexin V positive RBCs and plasma F1+2 had a significant increase and MTGT had a significant decrease in BTT subjects versus controls and in β0 group versus β+ group. MPTTK was significantly shorter in BTT subjects than controls, but no significant deference between BTT subjects. The percentage of annexin V positive RBCs showed a significant negative correlation with haemoglobin level, MTGT and MPTTK, and a significant positive correlation with plasma F1+2. Conclusion BTT subjects may have a risk of hypercoagulable state particularly in β0 genotype. Measurement of PS exposure on RBCs and the plasma F1+2 is useful to evaluate hypercoagulability state." @default.
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• W2071808146 date "2014-09-01" @default.
• W2071808146 modified "2023-09-27" @default.
• W2071808146 title "The hypercoagulable status in common Mediterranean β-thalassaemia mutations trait" @default.
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• W2071808146 doi "https://doi.org/10.1111/ijlh.12289" @default.
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