Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071824900> ?p ?o ?g. }
- W2071824900 endingPage "149" @default.
- W2071824900 startingPage "131" @default.
- W2071824900 abstract "Whether or not an individual’s drug metabolising capacity declines with advancing age is a vexing question. There is no clear evidence that drug metabolism itself (‘the biologically-assisted chemical alteration of the administered parent molecule’) is less efficient in healthy old age than at younger ages, whereas a decreased capacity may be associated with ill-health and frailty. However, elderly individuals do show a reduced enzyme induction capability and are less able to tolerate overdoses. It appears that the majority of deleterious clinical outcomes related to drug therapy in an elderly (usually ill or frail) population may be ascribed to various anatomical and physiological age-related changes. These may affect both pharmacodynamics and pharmacokinetics, but not necessarily drug metabolism. Information gleaned from animal studies undertaken mainly in rodents does not seem to be of relevance to humans and studies in healthy aged human populations may not highlight possible problems. However, certain circumstances may influence metabolic competence, and phenotyping rather than genotyping is of more value in identifying those susceptible to adverse drug reactions. This short review discusses the potential contributions of four factors (inflammation, circadian rhythm, gut microbes, epigenetic aspects) which may lead to alterations in drug metabolism with increasing age." @default.
- W2071824900 created "2016-06-24" @default.
- W2071824900 creator A5035279234 @default.
- W2071824900 creator A5065053109 @default.
- W2071824900 date "1988-01-01" @default.
- W2071824900 modified "2023-10-12" @default.
- W2071824900 title "Drug metabolism in the elderly" @default.
- W2071824900 cites W114438298 @default.
- W2071824900 cites W1468286270 @default.
- W2071824900 cites W1597569297 @default.
- W2071824900 cites W1963622354 @default.
- W2071824900 cites W1963743345 @default.
- W2071824900 cites W1965549499 @default.
- W2071824900 cites W1967619197 @default.
- W2071824900 cites W1969184569 @default.
- W2071824900 cites W1970059344 @default.
- W2071824900 cites W1970691224 @default.
- W2071824900 cites W1970731848 @default.
- W2071824900 cites W1971244664 @default.
- W2071824900 cites W1973569100 @default.
- W2071824900 cites W1974482912 @default.
- W2071824900 cites W1975788927 @default.
- W2071824900 cites W1978109120 @default.
- W2071824900 cites W1978643931 @default.
- W2071824900 cites W1978876180 @default.
- W2071824900 cites W1980003034 @default.
- W2071824900 cites W1980489201 @default.
- W2071824900 cites W1980857267 @default.
- W2071824900 cites W1981922710 @default.
- W2071824900 cites W1982249850 @default.
- W2071824900 cites W1983220171 @default.
- W2071824900 cites W1984590378 @default.
- W2071824900 cites W1986658269 @default.
- W2071824900 cites W1986914730 @default.
- W2071824900 cites W1987093394 @default.
- W2071824900 cites W1988399534 @default.
- W2071824900 cites W1992885005 @default.
- W2071824900 cites W1993825907 @default.
- W2071824900 cites W1993945174 @default.
- W2071824900 cites W1994420004 @default.
- W2071824900 cites W1995514808 @default.
- W2071824900 cites W1997193917 @default.
- W2071824900 cites W1997443051 @default.
- W2071824900 cites W1999153032 @default.
- W2071824900 cites W1999852053 @default.
- W2071824900 cites W2001324129 @default.
- W2071824900 cites W2003730847 @default.
- W2071824900 cites W2008274522 @default.
- W2071824900 cites W2010669389 @default.
- W2071824900 cites W2010687472 @default.
- W2071824900 cites W2012464391 @default.
- W2071824900 cites W2013739111 @default.
- W2071824900 cites W2013854344 @default.
- W2071824900 cites W2014977863 @default.
- W2071824900 cites W2015728398 @default.
- W2071824900 cites W2016042407 @default.
- W2071824900 cites W2020625319 @default.
- W2071824900 cites W2021474128 @default.
- W2071824900 cites W2022600005 @default.
- W2071824900 cites W2023437376 @default.
- W2071824900 cites W2024185962 @default.
- W2071824900 cites W2025697935 @default.
- W2071824900 cites W2026494346 @default.
- W2071824900 cites W2027618044 @default.
- W2071824900 cites W2027855370 @default.
- W2071824900 cites W2028868369 @default.
- W2071824900 cites W2030182098 @default.
- W2071824900 cites W2034599566 @default.
- W2071824900 cites W2039722188 @default.
- W2071824900 cites W2040190232 @default.
- W2071824900 cites W2042247296 @default.
- W2071824900 cites W2042894178 @default.
- W2071824900 cites W2046882523 @default.
- W2071824900 cites W2047764430 @default.
- W2071824900 cites W2052432072 @default.
- W2071824900 cites W2053541172 @default.
- W2071824900 cites W2054498117 @default.
- W2071824900 cites W2056000239 @default.
- W2071824900 cites W2056085393 @default.
- W2071824900 cites W2058739178 @default.
- W2071824900 cites W2060825487 @default.
- W2071824900 cites W2061069663 @default.
- W2071824900 cites W2061511535 @default.
- W2071824900 cites W2062767557 @default.
- W2071824900 cites W2063020863 @default.
- W2071824900 cites W2065423157 @default.
- W2071824900 cites W2065697509 @default.
- W2071824900 cites W2069041677 @default.
- W2071824900 cites W2069702563 @default.
- W2071824900 cites W2073461717 @default.
- W2071824900 cites W2074579548 @default.
- W2071824900 cites W2075876165 @default.
- W2071824900 cites W2076374173 @default.
- W2071824900 cites W2077875067 @default.
- W2071824900 cites W2080617384 @default.
- W2071824900 cites W2081190121 @default.
- W2071824900 cites W2082173168 @default.
- W2071824900 cites W2082425802 @default.