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• W2071832743 abstract "To report outcomes for breast cancer treated with breast-conserving therapy using accelerated partial breast irradiation (APBI) with interstitial multi-catheter brachytherapy by a cooperative group of institutions. Five institutions with extensive experience in treating select breast cancers with interstitial brachytherapy contributed their experience to this retrospective clinical study. From 1992 to 2013, 938 patients with breast cancer were treated with breast conserving surgery and adjuvant APBI using interstitial multi-catheter brachytherapy. Eight hundred forty-nine patients had followup information available to assess cancer related outcomes (local, regional, distant control). All patients underwent surgical excision and received 34 Gy in 10 fractions over 5 days with high-dose-rate Iridium-192. Mean age was 60.0±11 years old. Histologies treated included 623 (73%) with IDC, 157 (18%) with DCIS, 37 (4%) with ILC, and 32 (4%) with other. T stage was Tis, T1mic/T1a, T1b, T1c, ≥ T2, or unknown in 18.5, 10.1, 28.3, 34.9, 8.1, and 0.1%. Nodal status was Nx, N0, N0i+, N1a, or unknown in 14.6, 77.0, 1.4, 6.8, and 0.1%. ER/PR/Her2 was positive in 81, 66, and 5.5%. Cox multivariate analysis for local control was performed using receptor status, histology, age, T stage, and nodal status. There was a median followup of 4.3 years (range 0.003-20.9) for the 849 patients with followup information. The 5-year actuarial risk of an ipsilateral breast tumor recurrence was 3% for all patients (3.8% for DCIS, 3% for IDC, 0% for ILC, and 3.8% for other). Of the 34/849 (4.0%) local recurrences, 5/157 (3.2%), 27/623 (4.3%), and 2/32 (6.3%) were in patients with DCIS, IDC, or other histology at initial diagnosis. The types of recurrences were elsewhere failures in 26/34 (76%) cases, marginal misses in 5/34 (15%) cases, and true recurrences in 3/34 (9%) cases. Median time to any local failure was 9.8 years (0.08-1-18.3). Median time to failure of elsewhere failures, marginal misses, or a true recurrence were 11.5 years (0.08-18.3), 7 years (0.8_16.8), and 3 years (1.6-8.4). Mean age of patients with a local recurrence was 58.1±11.4 years. 6/849 (0.7%) and 12/849 (1.4%) patients developed a regional recurrence or distant metastasis with median time to occurrence of 2.8 (1-18.7) years and 4.8 (1.5-6.3) years. No factor on multivariate analysis was predictive of local recurrence This cooperative multi-institutional study is the largest published report of the outcomes of patients with breast cancer treated by interstitial brachytherapy. This radiotherapy method to complete breast conserving therapy was associated with excellent local control. These study results support the findings of the prospective interstitial APBI results from Europe and compare favorably with multiple week whole breast irradiation outcomes." @default.
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• W2071832743 date "2014-03-01" @default.
• W2071832743 modified "2023-09-27" @default.
• W2071832743 title "Interstitial Multi-Catheter Brachytherapy for Breast Cancer: A Multi-Institutional Study" @default.
• W2071832743 doi "https://doi.org/10.1016/j.brachy.2014.02.215" @default.
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