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• W2071833349 startingPage "17715" @default.
• W2071833349 abstract "A series of new aminomethylated derivatives of isoliquiritigenin was synthesized. The structures of the compounds were confirmed by IR, MS, NMR, 13C-NMR and elemental analyses. Cytotoxic activities of these derivatives towards the human prostatic cell line PC-3, human mammary cancer cell line MCF-7 and human oophoroma cell line HO-8910 in vitro were tested. The IC50 values showed cytotoxic activities of some of these new derivatives were relatively strong. Furthermore, tumor growth inhibition in vivo of aminomethylated derivatives of isoliquiritigenin 15 was superior to that of isoliquritigenin and reached inhibition rates of 71.68%. The detailed synthesis, spectroscopic data, biological and pharmacologicalactivities of the synthesized compounds were provided." @default.
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• W2071833349 date "2014-10-31" @default.
• W2071833349 modified "2023-10-04" @default.
• W2071833349 title "Synthesis and Anti-Tumor Activity of Novel Aminomethylated Derivatives of Isoliquiritigenin" @default.
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• W2071833349 doi "https://doi.org/10.3390/molecules191117715" @default.
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