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• W2071838265 abstract "Factors associated with duration of dementia in a consecutive series of 103 Alzheimer’s disease (AD) cases were studied using the Kaplan-Meier estimator and Cox regression analysis (proportional hazard model). Mean disease duration was 7.1 years (range: 6 weeks–30 years, standard deviation = 5.18); 25% of cases died within four years, 50% within 6.9 years, and 75% within 10 years. Familial AD cases (FAD) had a longer duration than sporadic cases (SAD), especially cases linked to presenilin ( PSEN ) genes. No significant differences in duration were associated with age, sex, or apolipoprotein E ( Apo E ) genotype. Duration was reduced in cases with arterial hypertension. Cox regression analysis suggested longer duration was associated with an earlier disease onset and increased senile plaque (SP) and neurofibrillary tangle (NFT) pathology in the orbital gyrus (OrG), CA1 sector of the hippocampus, and nucleus basalis of Meynert (NBM). The data suggest shorter disease duration in SAD and in cases with hypertensive comorbidity. In addition, degree of neuropathology did not influence survival, but spread of SP/NFT pathology into the frontal lobe, hippocampus, and basal forebrain was associated with longer disease duration." @default.
• W2071838265 created "2016-06-24" @default.
• W2071838265 creator A5040571169 @default.
• W2071838265 date "2014-01-01" @default.
• W2071838265 modified "2023-10-03" @default.
• W2071838265 title "Factors Determining Disease Duration in Alzheimer’s Disease: A Postmortem Study of 103 Cases Using the Kaplan-Meier Estimator and Cox Regression" @default.
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• W2071838265 doi "https://doi.org/10.1155/2014/623487" @default.
• W2071838265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3919116" @default.
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