FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071851593> ?p ?o ?g. }

• W2071851593 endingPage "2043" @default.
• W2071851593 startingPage "2034" @default.
• W2071851593 abstract "Stomatin, prohibitin, flotillin, and HflK/C (SPFH) domain proteins are membrane proteins that are widely conserved from bacteria to mammals. The molecular functions of these proteins have not been established. In mammals, the domain is often found in raft-associated proteins such as flotillin and podocin. We determined the structure of the SPFH domain of PH0470 derived from Pyrococcus horikoshii using NMR. The structure closely resembles that of the SPFH domain of the paralog PH1511, except for two C-terminal helices. The results show that the SPFH domain forms stable dimers, trimers, tetramers, and multimers, although it lacks the coiled-coil region for oligomerization, which is a highly conserved region in this protein family. The oligomers exhibited unusual thermodynamic behavior, as determined by circular dichroism, NMR, gel filtration, chemical cross-linking, and analytical ultracentrifugation. The oligomers were converted into monomers when they were heated once and then cooled. This transition was one-way and irreversible. We propose a mechanism of domain swapping for forming dimers as well as successive oligomers. The results of this study provide what to our knowledge are new insights into the common molecular function of the SPFH domain, which may act as a membrane skeleton through oligomerization by domain swapping." @default.
• W2071851593 created "2016-06-24" @default.
• W2071851593 creator A5001311929 @default.
• W2071851593 creator A5007145673 @default.
• W2071851593 creator A5022487976 @default.
• W2071851593 creator A5058132921 @default.
• W2071851593 creator A5083872117 @default.
• W2071851593 creator A5085080161 @default.
• W2071851593 creator A5086276958 @default.
• W2071851593 creator A5087138734 @default.
• W2071851593 creator A5091825124 @default.
• W2071851593 date "2009-10-01" @default.
• W2071851593 modified "2023-09-27" @default.
• W2071851593 title "Unusual Thermal Disassembly of the SPFH Domain Oligomer from Pyrococcus horikoshii" @default.
• W2071851593 cites W1589295940 @default.
• W2071851593 cites W1952903823 @default.
• W2071851593 cites W1967120563 @default.
• W2071851593 cites W1968283387 @default.
• W2071851593 cites W1972392332 @default.
• W2071851593 cites W1972807210 @default.
• W2071851593 cites W1976608130 @default.
• W2071851593 cites W1985309812 @default.
• W2071851593 cites W1992085369 @default.
• W2071851593 cites W1992144784 @default.
• W2071851593 cites W1997262127 @default.
• W2071851593 cites W1999746361 @default.
• W2071851593 cites W2002195659 @default.
• W2071851593 cites W2004935177 @default.
• W2071851593 cites W2016550460 @default.
• W2071851593 cites W2017949750 @default.
• W2071851593 cites W2025993347 @default.
• W2071851593 cites W2029227260 @default.
• W2071851593 cites W2040716137 @default.
• W2071851593 cites W2041725894 @default.
• W2071851593 cites W2051545925 @default.
• W2071851593 cites W2051763915 @default.
• W2071851593 cites W2055756637 @default.
• W2071851593 cites W2069663555 @default.
• W2071851593 cites W2072735392 @default.
• W2071851593 cites W2073013532 @default.
• W2071851593 cites W2093668760 @default.
• W2071851593 cites W2098613471 @default.
• W2071851593 cites W2104728214 @default.
• W2071851593 cites W2108560778 @default.
• W2071851593 cites W2121936687 @default.
• W2071851593 cites W2130900335 @default.
• W2071851593 cites W2147168163 @default.
• W2071851593 cites W2157831542 @default.
• W2071851593 cites W2169821755 @default.
• W2071851593 doi "https://doi.org/10.1016/j.bpj.2009.07.034" @default.
• W2071851593 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2756375" @default.
• W2071851593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19804735" @default.
• W2071851593 hasPublicationYear "2009" @default.
• W2071851593 type Work @default.
• W2071851593 sameAs 2071851593 @default.
• W2071851593 citedByCount "27" @default.
• W2071851593 countsByYear W20718515932012 @default.
• W2071851593 countsByYear W20718515932013 @default.
• W2071851593 countsByYear W20718515932014 @default.
• W2071851593 countsByYear W20718515932015 @default.
• W2071851593 countsByYear W20718515932016 @default.
• W2071851593 countsByYear W20718515932017 @default.
• W2071851593 countsByYear W20718515932018 @default.
• W2071851593 countsByYear W20718515932019 @default.
• W2071851593 countsByYear W20718515932020 @default.
• W2071851593 countsByYear W20718515932021 @default.
• W2071851593 countsByYear W20718515932022 @default.
• W2071851593 countsByYear W20718515932023 @default.
• W2071851593 crossrefType "journal-article" @default.
• W2071851593 hasAuthorship W2071851593A5001311929 @default.
• W2071851593 hasAuthorship W2071851593A5007145673 @default.
• W2071851593 hasAuthorship W2071851593A5022487976 @default.
• W2071851593 hasAuthorship W2071851593A5058132921 @default.
• W2071851593 hasAuthorship W2071851593A5083872117 @default.
• W2071851593 hasAuthorship W2071851593A5085080161 @default.
• W2071851593 hasAuthorship W2071851593A5086276958 @default.
• W2071851593 hasAuthorship W2071851593A5087138734 @default.
• W2071851593 hasAuthorship W2071851593A5091825124 @default.
• W2071851593 hasBestOaLocation W20718515931 @default.
• W2071851593 hasConcept C104317684 @default.
• W2071851593 hasConcept C107824862 @default.
• W2071851593 hasConcept C113027372 @default.
• W2071851593 hasConcept C115624301 @default.
• W2071851593 hasConcept C12554922 @default.
• W2071851593 hasConcept C133571119 @default.
• W2071851593 hasConcept C144292202 @default.
• W2071851593 hasConcept C153660203 @default.
• W2071851593 hasConcept C166940927 @default.
• W2071851593 hasConcept C167625842 @default.
• W2071851593 hasConcept C178790620 @default.
• W2071851593 hasConcept C185592680 @default.
• W2071851593 hasConcept C190283241 @default.
• W2071851593 hasConcept C25166345 @default.
• W2071851593 hasConcept C2775894526 @default.
• W2071851593 hasConcept C2776943354 @default.
• W2071851593 hasConcept C2778332380 @default.
• W2071851593 hasConcept C2780642029 @default.
• W2071851593 hasConcept C521977710 @default.

• next