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- W2071853212 abstract "The administration of 5-methoxy-N,N-di-methyl-tryptamine (5-MeODMT), 0–2.0 mg·kg−1 SC -15 min, produced a dose-dependent facilitation of the male rat sexual behavior, as evidenced by a decrease in the number of intromissions to ejaculation and in the ejaculation latency. The effects produced by 5-MeODMT (1 mg·kg−1) were antagonized by pindolol (4 mg·kg−1 SC -30 min), but not pirenperone (0.25 mg·kg−1 SC -30 min) or metergoline (1 mg·kg−1 SC -30 min), administration. As expected, 5-HTP (25 mg·kg−1 SC -60 min) produced an increased number of mounts and intromissions to ejaculation and an increase in the ejaculation latency in benserazide (25 mg·kg−1 SC -90 min) pretreated animals. Pindolol (4 mg·kg−1) by itself produced the same effects as seen after 5-HTP administration, and the combination of these compounds produced additive effects. Betaxocol (8 mg·kg−1 SC -30 min) had no effects of its own and did not interact with 5-HTP. The results suggest that stimulation of brain 5-HT1 or 5-HT2 receptors produces facilitation and inhibition, respectively, of the male rat sexual behavior." @default.
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- W2071853212 date "1991-01-01" @default.
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- W2071853212 title "Opposite effects of 5-methoxy-N,N-di-methyl-tryptamine and 5-hydroxytryptophan on male rat sexual behavior" @default.
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- W2071853212 doi "https://doi.org/10.1016/0091-3057(91)90611-5" @default.
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