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- W2071856265 abstract "1. The effects of bicyclic organophosphate esters (4-substituted 2,6,7-trioxa-1-phosphabicyclo [2.2.2]octane 1-oxides) on the miniature inhibitory junction potentials (m.i.j.p.s) of the longitudinal muscle of earthworm, Pheretimma communissima, were investigated. 2. Me-, i-Pr- and t-Bu-BPEs reduced the frequency and mean amplitude of m.i.j.p.s in the concentration of 10−5 g/ml. in which concentration picrotoxin showed only a small effect on the m.i.j.p. 3. In higher concentrations (2×10−5 g/ml – 5×10−5 g/ml) alkyl-BPEs completely blocked the generation of m.i.j.p.s. 4. On the contrary to the effects of alkyl-BPEs, NH2-BPE (5×10−5 g/ml) did not show any effect on the amplitude and the frequency of m.i.j.p.s. 5. BPEs (10−5 g/ml) did not exert any effects on the twitch contractions of frog and rat skeletal muscle induced by direct and indirect stimulations. 6. The different structure-toxicity relationships for BPEs in mammalian central nervous system and invertebrate peripheral neuro-muscular junction were discussed." @default.
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- W2071856265 title "The effects of bicyclic phosphate esters on the invertebrate and vertebrate neuro-muscular junctions" @default.
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- W2071856265 doi "https://doi.org/10.1016/0306-4492(77)90052-1" @default.
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