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- W2071857166 endingPage "846" @default.
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- W2071857166 abstract "A parkinsonian syndrome can be produced in nonhuman primates by administration of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Parkinsonian-like symptoms induced acutely by MPTP were ameliorated after treatment with GM1 ganglioside, a substance shown to have neurotrophic effects on the damaged dopamine system in rodents. Treatment with GM1 ganglioside also increased striatal dopamine and metabolite levels and enhanced the dopaminergic innervation of the striatum as demonstrated by tyrosine hydroxylase immunohistochemistry. These results suggest that GM1 ganglioside may hold promise as a therapeutic agent for the treatment of Parkinson's disease." @default.
- W2071857166 created "2016-06-24" @default.
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- W2071857166 date "1992-05-08" @default.
- W2071857166 modified "2023-09-27" @default.
- W2071857166 title "Recovery from experimental parkinsonism in primates with GM1 ganglioside treatment" @default.
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- W2071857166 doi "https://doi.org/10.1126/science.1350379" @default.
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