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- W2071859096 abstract "Sexual precocity at age 5 years was treated at age 6 years by radiation of an optic neurofibroma. Rapid pre-treatment growth rate and normal GH response to arginine-insulin provocation (ATT-ITT) were followed (post radiation) by decelerating growth rate with failure of GH response to ATT, ITT and during sleep. T4 fell to 1.6 μg% but TRH induced TSH release indicating hypothalamic deficiency and this was treated with L-T4 replacement. ACTH was normal (metyrapone test). FSH (390 ng% LER 907) and LH (96 ng%) were normal adult. Menarche at age 9 years was followed by amenorrhea. The data suggested selective hypothalamic damage. Therefore, estradiol 15 ng/kg/d was given IM × 5 days. FSH and LH were incompletely suppressed and both showed rebound after, but no “surge” during estrogen administration. Control → during estrogen → post control values respectively were FSH 310 -340; 190 - 224; 213 - 242 and LH 80 - 90; 43 - 74; 89 - 140 ng% LER 907. Conclusion: The data are consistent with the hypothesis that in this patient there was preservation of the “tonic” gonadotrophin releasing center with tumor and/or radiation damage to the “cyclic” center; anatomically the latter may be situated near the growth hormone and TRH releasing centers in the hypothalamus." @default.
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- W2071859096 date "1974-04-01" @default.
- W2071859096 modified "2023-09-25" @default.
- W2071859096 title "SEXUAL PRECOCITY SECONDARY TO OPTIC NEUROFIBROMATOSIS FOLLOWED BY 2° AMENORRHEA AND LOSS OF GH AND TSH WITH NORMAL ACTH AND TONIC FSH AND LH SECRETION" @default.
- W2071859096 doi "https://doi.org/10.1203/00006450-197404000-00160" @default.
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