Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071864317> ?p ?o ?g. }
- W2071864317 endingPage "918" @default.
- W2071864317 startingPage "911" @default.
- W2071864317 abstract "Lumbar cerebrospinal fluid (CSF) was collected from controls and neuroleptic-naive patients with their first acute schizophrenic episode. The CSF was analyzed for several biogenic amines and their metabolites [dopamine,dihydroxyphenylacetic acid (DOPAC), noradrenaline, 5-hydroxytryptamine (5-HT), 5-hydroxyindolacetic acid (5-HIAA)]. For these transmitters, which are stored and secreted from synaptic vesicles, there was no significant difference between controls and schizophrenic patients. As constituents of large dense-core vesicles substance P (SP) and GE-25 (derived from chromogranin A)-and secretoneurin (derived from secretogranin 11)-immunoreactivities were determined. SP-like immunoreactivity levels did not differ between controls and patients; however, GE-25 was elevated and especially the GE-25/secretoneurin ratio was significantly (p < .001) higher in patients. Characterization of the immunoreactivities by high-performance liquid chromatography did not reveal any difference between patients (n = 3) and controls in the processing of the two proproteins chromogranin A and secretogranin II. These data indicate that proteolytic processing of the two widespread constituents of large dense-core vesicles, i.e., chromogranin A and secretogranin II, is not altered in schizophrenic patients. The increase in the chromogranin A /secretoneurin ratio in schizophrenic patients deserves further investigation in order to elucidate its possible pathogenetic significance." @default.
- W2071864317 created "2016-06-24" @default.
- W2071864317 creator A5034073436 @default.
- W2071864317 creator A5037918334 @default.
- W2071864317 creator A5039420981 @default.
- W2071864317 creator A5045030140 @default.
- W2071864317 creator A5064929406 @default.
- W2071864317 creator A5080702509 @default.
- W2071864317 creator A5087916167 @default.
- W2071864317 creator A5089362417 @default.
- W2071864317 date "1996-06-01" @default.
- W2071864317 modified "2023-09-26" @default.
- W2071864317 title "CSF of neuroleptic-naive first-episode schizophrenic patients: Levels of biogenic amines, substance P, and peptides derived from chromogranin A (GE-25) and secretogranin II (secretoneurin)" @default.
- W2071864317 cites W1496463431 @default.
- W2071864317 cites W1603590032 @default.
- W2071864317 cites W1783614608 @default.
- W2071864317 cites W1964219717 @default.
- W2071864317 cites W1970082985 @default.
- W2071864317 cites W1973485483 @default.
- W2071864317 cites W1983449826 @default.
- W2071864317 cites W1983766539 @default.
- W2071864317 cites W1985009927 @default.
- W2071864317 cites W1985129085 @default.
- W2071864317 cites W1986127123 @default.
- W2071864317 cites W1995005137 @default.
- W2071864317 cites W1998950018 @default.
- W2071864317 cites W2000740138 @default.
- W2071864317 cites W2000775740 @default.
- W2071864317 cites W2002782021 @default.
- W2071864317 cites W2007838461 @default.
- W2071864317 cites W2008774709 @default.
- W2071864317 cites W2010814581 @default.
- W2071864317 cites W2016312600 @default.
- W2071864317 cites W2020844317 @default.
- W2071864317 cites W2022098657 @default.
- W2071864317 cites W2031188156 @default.
- W2071864317 cites W2040083328 @default.
- W2071864317 cites W2040123079 @default.
- W2071864317 cites W2048141191 @default.
- W2071864317 cites W2055508158 @default.
- W2071864317 cites W2058687306 @default.
- W2071864317 cites W2061967473 @default.
- W2071864317 cites W2062477634 @default.
- W2071864317 cites W2062921045 @default.
- W2071864317 cites W2063944659 @default.
- W2071864317 cites W2063952421 @default.
- W2071864317 cites W2066099778 @default.
- W2071864317 cites W2066749726 @default.
- W2071864317 cites W2067027667 @default.
- W2071864317 cites W2069150043 @default.
- W2071864317 cites W2070437724 @default.
- W2071864317 cites W2078271589 @default.
- W2071864317 cites W2078520201 @default.
- W2071864317 cites W2084219574 @default.
- W2071864317 cites W2087005427 @default.
- W2071864317 cites W2090391179 @default.
- W2071864317 cites W2091074303 @default.
- W2071864317 cites W2092294784 @default.
- W2071864317 cites W2092657822 @default.
- W2071864317 cites W2094530047 @default.
- W2071864317 cites W2159988573 @default.
- W2071864317 cites W21800075 @default.
- W2071864317 cites W2308223254 @default.
- W2071864317 cites W2750455178 @default.
- W2071864317 doi "https://doi.org/10.1016/0006-3223(95)00098-4" @default.
- W2071864317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9162202" @default.
- W2071864317 hasPublicationYear "1996" @default.
- W2071864317 type Work @default.
- W2071864317 sameAs 2071864317 @default.
- W2071864317 citedByCount "44" @default.
- W2071864317 countsByYear W20718643172012 @default.
- W2071864317 countsByYear W20718643172013 @default.
- W2071864317 countsByYear W20718643172015 @default.
- W2071864317 countsByYear W20718643172017 @default.
- W2071864317 countsByYear W20718643172018 @default.
- W2071864317 countsByYear W20718643172019 @default.
- W2071864317 countsByYear W20718643172021 @default.
- W2071864317 countsByYear W20718643172022 @default.
- W2071864317 countsByYear W20718643172023 @default.
- W2071864317 crossrefType "journal-article" @default.
- W2071864317 hasAuthorship W2071864317A5034073436 @default.
- W2071864317 hasAuthorship W2071864317A5037918334 @default.
- W2071864317 hasAuthorship W2071864317A5039420981 @default.
- W2071864317 hasAuthorship W2071864317A5045030140 @default.
- W2071864317 hasAuthorship W2071864317A5064929406 @default.
- W2071864317 hasAuthorship W2071864317A5080702509 @default.
- W2071864317 hasAuthorship W2071864317A5087916167 @default.
- W2071864317 hasAuthorship W2071864317A5089362417 @default.
- W2071864317 hasConcept C126322002 @default.
- W2071864317 hasConcept C134018914 @default.
- W2071864317 hasConcept C185592680 @default.
- W2071864317 hasConcept C204232928 @default.
- W2071864317 hasConcept C2779651940 @default.
- W2071864317 hasConcept C513476851 @default.
- W2071864317 hasConcept C71924100 @default.
- W2071864317 hasConcept C77231918 @default.
- W2071864317 hasConceptScore W2071864317C126322002 @default.
- W2071864317 hasConceptScore W2071864317C134018914 @default.