Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071874416> ?p ?o ?g. }
- W2071874416 endingPage "278" @default.
- W2071874416 startingPage "270" @default.
- W2071874416 abstract "The highly dynamic membranous network of eukaryotic cells allows spatial organization of biochemical reactions to suit the complex metabolic needs of the cell. The unique lipid composition of organelle membranes in the face of dynamic membrane activities assumes that lipid gradients are constantly generated and maintained. Important advances have been made in identifying specialized membrane compartments and lipid transfer mechanisms that are critical for generating and maintaining lipid gradients. Remarkably, one class of minor phospholipids – the phosphoinositides – is emerging as important regulators of these processes. Here, we summarize several lines of research that have led to our current understanding of the connection between phosphoinositides and the transport of structural lipids and offer some thoughts on general principles possibly governing these processes. The highly dynamic membranous network of eukaryotic cells allows spatial organization of biochemical reactions to suit the complex metabolic needs of the cell. The unique lipid composition of organelle membranes in the face of dynamic membrane activities assumes that lipid gradients are constantly generated and maintained. Important advances have been made in identifying specialized membrane compartments and lipid transfer mechanisms that are critical for generating and maintaining lipid gradients. Remarkably, one class of minor phospholipids – the phosphoinositides – is emerging as important regulators of these processes. Here, we summarize several lines of research that have led to our current understanding of the connection between phosphoinositides and the transport of structural lipids and offer some thoughts on general principles possibly governing these processes." @default.
- W2071874416 created "2016-06-24" @default.
- W2071874416 creator A5002060563 @default.
- W2071874416 creator A5021531343 @default.
- W2071874416 creator A5050743363 @default.
- W2071874416 date "2013-06-01" @default.
- W2071874416 modified "2023-10-15" @default.
- W2071874416 title "Inositol lipid regulation of lipid transfer in specialized membrane domains" @default.
- W2071874416 cites W1042686957 @default.
- W2071874416 cites W1566203574 @default.
- W2071874416 cites W1566522647 @default.
- W2071874416 cites W1695245462 @default.
- W2071874416 cites W1964679889 @default.
- W2071874416 cites W1970666556 @default.
- W2071874416 cites W1974119640 @default.
- W2071874416 cites W1975630134 @default.
- W2071874416 cites W1979104861 @default.
- W2071874416 cites W1980188948 @default.
- W2071874416 cites W1980939512 @default.
- W2071874416 cites W1981728739 @default.
- W2071874416 cites W1984592684 @default.
- W2071874416 cites W1986194352 @default.
- W2071874416 cites W1993083084 @default.
- W2071874416 cites W1993445637 @default.
- W2071874416 cites W1996977823 @default.
- W2071874416 cites W1998000396 @default.
- W2071874416 cites W1998749044 @default.
- W2071874416 cites W1999698113 @default.
- W2071874416 cites W2000665911 @default.
- W2071874416 cites W2001956269 @default.
- W2071874416 cites W2003324016 @default.
- W2071874416 cites W2004530752 @default.
- W2071874416 cites W2005445415 @default.
- W2071874416 cites W2014253236 @default.
- W2071874416 cites W2015536770 @default.
- W2071874416 cites W2018762738 @default.
- W2071874416 cites W2019442017 @default.
- W2071874416 cites W2019889005 @default.
- W2071874416 cites W2025131017 @default.
- W2071874416 cites W2026359346 @default.
- W2071874416 cites W2027704731 @default.
- W2071874416 cites W2028606847 @default.
- W2071874416 cites W2029127632 @default.
- W2071874416 cites W2029572675 @default.
- W2071874416 cites W2029878872 @default.
- W2071874416 cites W2031468878 @default.
- W2071874416 cites W2037668562 @default.
- W2071874416 cites W2041337446 @default.
- W2071874416 cites W2043597075 @default.
- W2071874416 cites W2046526649 @default.
- W2071874416 cites W2049508769 @default.
- W2071874416 cites W2051444072 @default.
- W2071874416 cites W2058706417 @default.
- W2071874416 cites W2058992886 @default.
- W2071874416 cites W2059637730 @default.
- W2071874416 cites W2062197104 @default.
- W2071874416 cites W2064892346 @default.
- W2071874416 cites W2065591224 @default.
- W2071874416 cites W2068808513 @default.
- W2071874416 cites W2070832223 @default.
- W2071874416 cites W2071379461 @default.
- W2071874416 cites W2074929978 @default.
- W2071874416 cites W2076554898 @default.
- W2071874416 cites W2077506140 @default.
- W2071874416 cites W2079071687 @default.
- W2071874416 cites W2079559417 @default.
- W2071874416 cites W2081351003 @default.
- W2071874416 cites W2081681270 @default.
- W2071874416 cites W2082315075 @default.
- W2071874416 cites W2085035388 @default.
- W2071874416 cites W2086620006 @default.
- W2071874416 cites W2086636140 @default.
- W2071874416 cites W2087801016 @default.
- W2071874416 cites W2088388436 @default.
- W2071874416 cites W2091061873 @default.
- W2071874416 cites W2092771390 @default.
- W2071874416 cites W2094068658 @default.
- W2071874416 cites W2094093650 @default.
- W2071874416 cites W2104256906 @default.
- W2071874416 cites W2105219787 @default.
- W2071874416 cites W2106178605 @default.
- W2071874416 cites W2106754534 @default.
- W2071874416 cites W2116951518 @default.
- W2071874416 cites W2119318973 @default.
- W2071874416 cites W2124393593 @default.
- W2071874416 cites W2126736952 @default.
- W2071874416 cites W2134303620 @default.
- W2071874416 cites W2155318092 @default.
- W2071874416 cites W2156351566 @default.
- W2071874416 cites W2160816118 @default.
- W2071874416 cites W2161923873 @default.
- W2071874416 cites W2164080428 @default.
- W2071874416 cites W2168930995 @default.
- W2071874416 cites W2170369801 @default.
- W2071874416 cites W29951261 @default.
- W2071874416 cites W331717834 @default.
- W2071874416 doi "https://doi.org/10.1016/j.tcb.2013.01.009" @default.
- W2071874416 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3665726" @default.