FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071877471> ?p ?o ?g. }

• W2071877471 endingPage "200" @default.
• W2071877471 startingPage "193" @default.
• W2071877471 abstract "Endophilin 1 is a presynaptically enriched protein which binds the GTPase dynamin and the polyphosphoinositide phosphatase synptojanin. Perturbation of endophilin function in cell-free systems and in a living synapse has implicated endophilin in endocytic vesicle budding (Ringstad, N., H. Gad, P. Low, G. Di Paolo, L. Brodin, O. Shupliakov, and P. De Camilli. 1999. Neuron. 24:143-154; Schmidt, A., M. Wolde, C. Thiele, W. Fest, H. Kratzin, A.V. Podtelejnikov, W. Witke, W.B. Huttner, and H.D. Soling. 1999. Nature. 401:133-141; Gad, H., N. Ringstad, P. Low, O. Kjaerulff, J. Gustafsson, M. Wenk, G. Di Paolo, Y. Nemoto, J. Crun, M.H. Ellisman, et al. 2000. Neuron. 27:301-312). Here, we show that purified endophilin can directly bind and evaginate lipid bilayers into narrow tubules similar in diameter to the neck of a clathrin-coated bud, providing new insight into the mechanisms through which endophilin may participate in membrane deformation and vesicle budding. This property of endophilin is independent of its putative lysophosphatydic acid acyl transferase activity, is mediated by its NH2-terminal region, and requires an amino acid stretch homologous to a corresponding region in amphiphysin, a protein previously shown to have similar effects on lipid bilayers (Takei, K., V.I. Slepnev, V. Haucke, and P. De Camilli. 1999. Nat. Cell Biol. 1:33-39). Endophilin cooligomerizes with dynamin rings on lipid tubules and inhibits dynamin's GTP-dependent vesiculating activity. Endophilin B, a protein with homology to endophilin 1, partially localizes to the Golgi complex and also deforms lipid bilayers into tubules, underscoring a potential role of endophilin family members in diverse tubulovesicular membrane-trafficking events in the cell." @default.
• W2071877471 created "2016-06-24" @default.
• W2071877471 creator A5005967948 @default.
• W2071877471 creator A5007348475 @default.
• W2071877471 creator A5028932993 @default.
• W2071877471 creator A5037459294 @default.
• W2071877471 creator A5049447022 @default.
• W2071877471 creator A5069591604 @default.
• W2071877471 date "2001-10-15" @default.
• W2071877471 modified "2023-10-17" @default.
• W2071877471 title "Generation of high curvature membranes mediated by direct endophilin bilayer interactions" @default.
• W2071877471 cites W1574831557 @default.
• W2071877471 cites W1972812883 @default.
• W2071877471 cites W1975081377 @default.
• W2071877471 cites W1978627586 @default.
• W2071877471 cites W1997719326 @default.
• W2071877471 cites W1999679029 @default.
• W2071877471 cites W2005440054 @default.
• W2071877471 cites W2008773520 @default.
• W2071877471 cites W2031907844 @default.
• W2071877471 cites W2033021180 @default.
• W2071877471 cites W2037425715 @default.
• W2071877471 cites W2040124514 @default.
• W2071877471 cites W2042776102 @default.
• W2071877471 cites W2076364749 @default.
• W2071877471 cites W2143369277 @default.
• W2071877471 cites W2159422521 @default.
• W2071877471 cites W2172095199 @default.
• W2071877471 doi "https://doi.org/10.1083/jcb.200107075" @default.
• W2071877471 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2198845" @default.
• W2071877471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11604418" @default.
• W2071877471 hasPublicationYear "2001" @default.
• W2071877471 type Work @default.
• W2071877471 sameAs 2071877471 @default.
• W2071877471 citedByCount "560" @default.
• W2071877471 countsByYear W20718774712012 @default.
• W2071877471 countsByYear W20718774712013 @default.
• W2071877471 countsByYear W20718774712014 @default.
• W2071877471 countsByYear W20718774712015 @default.
• W2071877471 countsByYear W20718774712016 @default.
• W2071877471 countsByYear W20718774712017 @default.
• W2071877471 countsByYear W20718774712018 @default.
• W2071877471 countsByYear W20718774712019 @default.
• W2071877471 countsByYear W20718774712020 @default.
• W2071877471 countsByYear W20718774712021 @default.
• W2071877471 countsByYear W20718774712022 @default.
• W2071877471 countsByYear W20718774712023 @default.
• W2071877471 crossrefType "journal-article" @default.
• W2071877471 hasAuthorship W2071877471A5005967948 @default.
• W2071877471 hasAuthorship W2071877471A5007348475 @default.
• W2071877471 hasAuthorship W2071877471A5028932993 @default.
• W2071877471 hasAuthorship W2071877471A5037459294 @default.
• W2071877471 hasAuthorship W2071877471A5049447022 @default.
• W2071877471 hasAuthorship W2071877471A5069591604 @default.
• W2071877471 hasBestOaLocation W20718774711 @default.
• W2071877471 hasConcept C130316041 @default.
• W2071877471 hasConcept C1491633281 @default.
• W2071877471 hasConcept C156407911 @default.
• W2071877471 hasConcept C185592680 @default.
• W2071877471 hasConcept C207332259 @default.
• W2071877471 hasConcept C2780976139 @default.
• W2071877471 hasConcept C28005876 @default.
• W2071877471 hasConcept C39944091 @default.
• W2071877471 hasConcept C41625074 @default.
• W2071877471 hasConcept C55493867 @default.
• W2071877471 hasConcept C79747257 @default.
• W2071877471 hasConcept C86803240 @default.
• W2071877471 hasConcept C95444343 @default.
• W2071877471 hasConceptScore W2071877471C130316041 @default.
• W2071877471 hasConceptScore W2071877471C1491633281 @default.
• W2071877471 hasConceptScore W2071877471C156407911 @default.
• W2071877471 hasConceptScore W2071877471C185592680 @default.
• W2071877471 hasConceptScore W2071877471C207332259 @default.
• W2071877471 hasConceptScore W2071877471C2780976139 @default.
• W2071877471 hasConceptScore W2071877471C28005876 @default.
• W2071877471 hasConceptScore W2071877471C39944091 @default.
• W2071877471 hasConceptScore W2071877471C41625074 @default.
• W2071877471 hasConceptScore W2071877471C55493867 @default.
• W2071877471 hasConceptScore W2071877471C79747257 @default.
• W2071877471 hasConceptScore W2071877471C86803240 @default.
• W2071877471 hasConceptScore W2071877471C95444343 @default.
• W2071877471 hasIssue "2" @default.
• W2071877471 hasLocation W20718774711 @default.
• W2071877471 hasLocation W20718774712 @default.
• W2071877471 hasLocation W20718774713 @default.
• W2071877471 hasLocation W20718774714 @default.
• W2071877471 hasLocation W20718774715 @default.
• W2071877471 hasOpenAccess W2071877471 @default.
• W2071877471 hasPrimaryLocation W20718774711 @default.
• W2071877471 hasRelatedWork W1590596761 @default.
• W2071877471 hasRelatedWork W1971065575 @default.
• W2071877471 hasRelatedWork W2001674490 @default.
• W2071877471 hasRelatedWork W2007118279 @default.
• W2071877471 hasRelatedWork W2035358727 @default.
• W2071877471 hasRelatedWork W2079661869 @default.
• W2071877471 hasRelatedWork W2129324236 @default.
• W2071877471 hasRelatedWork W2133716663 @default.
• W2071877471 hasRelatedWork W2166863817 @default.

• next