Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071884103> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2071884103 abstract "1. The effects of nifedipine on both levcromakalim-induced membrane currents and unitary currents in pig proximal urethra were investigated by use of patch-clamp techniques (conventional whole-cell configuration and cell-attached patches). 2. Nifedipine had a voltage-dependent inhibitory effect on voltage-dependent Ba2+ currents at - 50 mV (Ki=30.6 nM). 3. In current-clamp mode, subsequent application of higher concentrations of nifedipine (> or =30 microM) caused a significant depolarization even after the membrane potential had been hyperpolarized to approximately -82 mV by application of 100 microM levcromakalim. 4. The 100 microM levcromakalim-induced inward current (symmetrical 140 mM K+ conditions, -50 mV) was inhibited by additional application of three different types of Ca antagonists (nifedipine, verapamil and diltiazem, all at 100 microM). In contrast, Bay K 8644 (1 microM) possessed no activating effect on the amplitude of this glibenclamide-sensitive current. 5. When 100 microM nifedipine was included in the pipette solution during conventional whole-cell recording at -50 mV, application of levcromakalim (100 microM) caused a significant inward membrane current which was suppressed by 5 microM glibenclamide. On the other hand, inclusion of 5 microM glibenclamide in the pipette solution prevented levcromakalim from inducing an inward membrane current. 6. The levcromakalim-induced K+ channel openings in cell-attached configuration were suppressed by subsequent application of 5 microM glibenclamide but not of 100 microM nifedipine. 7. These results suggest that in pig proximal urethra, nifedipine inhibits the glibenclamide-sensitive 43 pS K+ channel activity mainly through extracellular blocking actions on the K+ channel itself." @default.
- W2071884103 created "2016-06-24" @default.
- W2071884103 creator A5073572662 @default.
- W2071884103 creator A5089050384 @default.
- W2071884103 date "1998-04-01" @default.
- W2071884103 modified "2023-09-24" @default.
- W2071884103 title "The effects of nifedipine and other calcium antagonists on the glibenclamide-sensitive K+ currents in smooth muscle cells from pig urethra" @default.
- W2071884103 cites W1982801829 @default.
- W2071884103 cites W1984172545 @default.
- W2071884103 cites W1987134158 @default.
- W2071884103 cites W1992035940 @default.
- W2071884103 cites W2008083291 @default.
- W2071884103 cites W2009667219 @default.
- W2071884103 cites W2010069520 @default.
- W2071884103 cites W2023651235 @default.
- W2071884103 cites W2026331038 @default.
- W2071884103 cites W2026483040 @default.
- W2071884103 cites W2029379652 @default.
- W2071884103 cites W2033462985 @default.
- W2071884103 cites W2039103542 @default.
- W2071884103 cites W2075393822 @default.
- W2071884103 cites W2081261629 @default.
- W2071884103 cites W2083584165 @default.
- W2071884103 cites W2095370348 @default.
- W2071884103 cites W2095793141 @default.
- W2071884103 cites W2105767595 @default.
- W2071884103 cites W2105954687 @default.
- W2071884103 cites W2249961135 @default.
- W2071884103 cites W2253288071 @default.
- W2071884103 doi "https://doi.org/10.1038/sj.bjp.0701777" @default.
- W2071884103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1565332" @default.
- W2071884103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9605567" @default.
- W2071884103 hasPublicationYear "1998" @default.
- W2071884103 type Work @default.
- W2071884103 sameAs 2071884103 @default.
- W2071884103 citedByCount "21" @default.
- W2071884103 countsByYear W20718841032015 @default.
- W2071884103 countsByYear W20718841032016 @default.
- W2071884103 countsByYear W20718841032020 @default.
- W2071884103 crossrefType "journal-article" @default.
- W2071884103 hasAuthorship W2071884103A5073572662 @default.
- W2071884103 hasAuthorship W2071884103A5089050384 @default.
- W2071884103 hasBestOaLocation W20718841032 @default.
- W2071884103 hasConcept C100837961 @default.
- W2071884103 hasConcept C12554922 @default.
- W2071884103 hasConcept C126322002 @default.
- W2071884103 hasConcept C134018914 @default.
- W2071884103 hasConcept C147944092 @default.
- W2071884103 hasConcept C178790620 @default.
- W2071884103 hasConcept C181911157 @default.
- W2071884103 hasConcept C185263204 @default.
- W2071884103 hasConcept C185592680 @default.
- W2071884103 hasConcept C2779066535 @default.
- W2071884103 hasConcept C2779768347 @default.
- W2071884103 hasConcept C2781391105 @default.
- W2071884103 hasConcept C4141045 @default.
- W2071884103 hasConcept C519063684 @default.
- W2071884103 hasConcept C55493867 @default.
- W2071884103 hasConcept C555293320 @default.
- W2071884103 hasConcept C71924100 @default.
- W2071884103 hasConcept C86803240 @default.
- W2071884103 hasConceptScore W2071884103C100837961 @default.
- W2071884103 hasConceptScore W2071884103C12554922 @default.
- W2071884103 hasConceptScore W2071884103C126322002 @default.
- W2071884103 hasConceptScore W2071884103C134018914 @default.
- W2071884103 hasConceptScore W2071884103C147944092 @default.
- W2071884103 hasConceptScore W2071884103C178790620 @default.
- W2071884103 hasConceptScore W2071884103C181911157 @default.
- W2071884103 hasConceptScore W2071884103C185263204 @default.
- W2071884103 hasConceptScore W2071884103C185592680 @default.
- W2071884103 hasConceptScore W2071884103C2779066535 @default.
- W2071884103 hasConceptScore W2071884103C2779768347 @default.
- W2071884103 hasConceptScore W2071884103C2781391105 @default.
- W2071884103 hasConceptScore W2071884103C4141045 @default.
- W2071884103 hasConceptScore W2071884103C519063684 @default.
- W2071884103 hasConceptScore W2071884103C55493867 @default.
- W2071884103 hasConceptScore W2071884103C555293320 @default.
- W2071884103 hasConceptScore W2071884103C71924100 @default.
- W2071884103 hasConceptScore W2071884103C86803240 @default.
- W2071884103 hasLocation W20718841031 @default.
- W2071884103 hasLocation W20718841032 @default.
- W2071884103 hasLocation W20718841033 @default.
- W2071884103 hasLocation W20718841034 @default.
- W2071884103 hasOpenAccess W2071884103 @default.
- W2071884103 hasPrimaryLocation W20718841031 @default.
- W2071884103 hasRelatedWork W1693695321 @default.
- W2071884103 hasRelatedWork W1977151728 @default.
- W2071884103 hasRelatedWork W1977737987 @default.
- W2071884103 hasRelatedWork W2011495679 @default.
- W2071884103 hasRelatedWork W2014609720 @default.
- W2071884103 hasRelatedWork W2071884103 @default.
- W2071884103 hasRelatedWork W2077087457 @default.
- W2071884103 hasRelatedWork W2081444879 @default.
- W2071884103 hasRelatedWork W2395125296 @default.
- W2071884103 hasRelatedWork W2414081612 @default.
- W2071884103 isParatext "false" @default.
- W2071884103 isRetracted "false" @default.
- W2071884103 magId "2071884103" @default.
- W2071884103 workType "article" @default.