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- W2071887987 abstract "Nervous system function is mediated by a precisely patterned network of synaptic connections. While several cell-adhesion and secreted molecules promote the assembly of synapses, the contribution of signals that negatively regulate synaptogenesis is not well understood. We examined synapse formation in the Caenorhabditis elegans motor neuron DA9, whose presynapses are restricted to a specific segment of its axon. We report that the Wnt lin-44 localizes the Wnt receptor lin-17/Frizzled (Fz) to a subdomain of the DA9 axon that is devoid of presynaptic specializations. When this signaling pathway, composed of the Wnts lin-44 and egl-20, lin-17/Frizzled and dsh-1/Dishevelled, is compromised, synapses develop ectopically in this subdomain. Conversely, overexpression of LIN-44 in cells adjacent to DA9 is sufficient to expand LIN-17 localization within the DA9 axon, thereby inhibiting presynaptic assembly. These results suggest that morphogenetic signals can spatially regulate the patterning of synaptic connections by subdividing an axon into discrete domains." @default.
- W2071887987 created "2016-06-24" @default.
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- W2071887987 date "2007-08-01" @default.
- W2071887987 modified "2023-10-16" @default.
- W2071887987 title "Wnt Signaling Positions Neuromuscular Connectivity by Inhibiting Synapse Formation in C. elegans" @default.
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- W2071887987 doi "https://doi.org/10.1016/j.cell.2007.06.046" @default.
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