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- W2071891661 abstract "ObjectiveTo assess the involvement of interleukin-18 (IL-18) in the pathophysiology of severe ovarian hyperstimulation syndrome (OHSS), and study its use as a marker of disease and its correlation to capillary hyperpermeability.DesignProspective controlled study.SettingAn IVF unit in a tertiary medical center.Patient(s)Twenty-four patients with OHSS in an IVF program, two control groups: group 1, 40 healthy age-matched women without ovulation-induction treatment; group 2, 19 women who received the same ovulation-induction regimen without experiencing OHSS.Intervention(s)Blood samples were obtained at three times: during acute OHSS, on significant clinical improvement, after complete resolution. Ascitic and pleural fluids were obtained by therapeutic paracentesis. Serum, peritoneal, and pleural fluids were analyzed for IL-18 and IL-6, and blood for hematocrit, white blood cell count, and E2 levels.Main outcome measure(s)Hematocrit white blood cell count, serum, peritoneal, pleural fluid levels of IL-18, IL-6, E2 in severe OHSS.Result(s)Significantly higher IL-18 levels were detected in serum, peritoneal, and pleural fluids of patients with severe OHSS as compared with both control groups. Serum IL-18 dropped significantly on transition to the diuretic phase and resolution. A statistically significant correlation between serum IL-18 and hyperpermeability characteristics (white blood cell count, hematocrit), serum E2, and IL-6 levels was recorded.Conclusion(s)This is the first study suggesting a role of IL-18 as a marker of OHSS, with correlation to capillary hyperpermeability parameters." @default.
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- W2071891661 date "2004-08-01" @default.
- W2071891661 modified "2023-09-27" @default.
- W2071891661 title "Interleukin-18 levels correlate with severe ovarian hyperstimulation syndrome" @default.
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- W2071891661 doi "https://doi.org/10.1016/j.fertnstert.2004.03.024" @default.
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