FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071893696> ?p ?o ?g. }

• W2071893696 endingPage "e946" @default.
• W2071893696 startingPage "e946" @default.
• W2071893696 abstract "MicroRNAs (miRNAs) are endogenous small noncoding RNA gene products, on average 22 nt long, found in a wide variety of organisms. They play important regulatory roles by targeting mRNAs for degradation or translational repression. There are 377 known mouse miRNAs and 475 known human miRNAs in the May 2007 release of the miRBase database, the majority of which are conserved between the two species. A number of recent reports imply that it is likely that many mammalian miRNAs remain to be discovered. The possibility that there are more of them expressed at lower levels or in more specialized expression contexts calls for the exploitation of genome sequence information to accelerate their discovery.In this article, we describe a computational method-mirCoS-that uses three support vector machine models sequentially to discover new miRNA candidates in mammalian genomes based on sequence, secondary structure, and conservation. mirCoS can efficiently detect the majority of known miRNAs and predicts an extensive set of hairpin structures based on human-mouse comparisons. In total, 3476 mouse candidates and 3441 human candidates were found. These hairpins are more similar to known miRNAs than to negative controls in several aspects not considered by the prediction algorithm. A significant fraction of predictions is supported by existing expression evidence.Using a novel approach, mirCoS performs comparably to or better than existing miRNA prediction methods, and contributes a significant number of new candidate miRNAs for experimental verification." @default.
• W2071893696 created "2016-06-24" @default.
• W2071893696 creator A5013333111 @default.
• W2071893696 creator A5052661284 @default.
• W2071893696 creator A5058825905 @default.
• W2071893696 date "2007-09-26" @default.
• W2071893696 modified "2023-10-14" @default.
• W2071893696 title "Mammalian MicroRNA Prediction through a Support Vector Machine Model of Sequence and Structure" @default.
• W2071893696 cites W144423133 @default.
• W2071893696 cites W1531954825 @default.
• W2071893696 cites W1845151788 @default.
• W2071893696 cites W1920564293 @default.
• W2071893696 cites W1963590211 @default.
• W2071893696 cites W1965100590 @default.
• W2071893696 cites W1965306643 @default.
• W2071893696 cites W1973876456 @default.
• W2071893696 cites W1974736226 @default.
• W2071893696 cites W1977940795 @default.
• W2071893696 cites W1984948945 @default.
• W2071893696 cites W1985738984 @default.
• W2071893696 cites W2009818318 @default.
• W2071893696 cites W2012453729 @default.
• W2071893696 cites W2013787825 @default.
• W2071893696 cites W2025289680 @default.
• W2071893696 cites W2027364181 @default.
• W2071893696 cites W2038766179 @default.
• W2071893696 cites W2040191060 @default.
• W2071893696 cites W2042673698 @default.
• W2071893696 cites W2060317992 @default.
• W2071893696 cites W2073718731 @default.
• W2071893696 cites W2075018560 @default.
• W2071893696 cites W2079869499 @default.
• W2071893696 cites W2083381199 @default.
• W2071893696 cites W2088431202 @default.
• W2071893696 cites W2092902314 @default.
• W2071893696 cites W2093213907 @default.
• W2071893696 cites W2095734937 @default.
• W2071893696 cites W2099468911 @default.
• W2071893696 cites W2100990361 @default.
• W2071893696 cites W2105554710 @default.
• W2071893696 cites W2106144124 @default.
• W2071893696 cites W2106929712 @default.
• W2071893696 cites W2107635158 @default.
• W2071893696 cites W2108292745 @default.
• W2071893696 cites W2109745159 @default.
• W2071893696 cites W2111629903 @default.
• W2071893696 cites W2112132489 @default.
• W2071893696 cites W2112192177 @default.
• W2071893696 cites W2116251070 @default.
• W2071893696 cites W2121487483 @default.
• W2071893696 cites W2122598328 @default.
• W2071893696 cites W2123159256 @default.
• W2071893696 cites W2124268899 @default.
• W2071893696 cites W2130979840 @default.
• W2071893696 cites W2135613885 @default.
• W2071893696 cites W2136846651 @default.
• W2071893696 cites W2137257434 @default.
• W2071893696 cites W2138910750 @default.
• W2071893696 cites W2139791626 @default.
• W2071893696 cites W2145191876 @default.
• W2071893696 cites W2146620899 @default.
• W2071893696 cites W2149429041 @default.
• W2071893696 cites W2150375453 @default.
• W2071893696 cites W2150770935 @default.
• W2071893696 cites W2151922790 @default.
• W2071893696 cites W2152320398 @default.
• W2071893696 cites W2152327613 @default.
• W2071893696 cites W2155237411 @default.
• W2071893696 cites W2155440340 @default.
• W2071893696 cites W2156186883 @default.
• W2071893696 cites W2156847802 @default.
• W2071893696 cites W2158826174 @default.
• W2071893696 cites W2159558399 @default.
• W2071893696 cites W2161283857 @default.
• W2071893696 cites W2165764599 @default.
• W2071893696 cites W2168230240 @default.
• W2071893696 cites W2168783124 @default.
• W2071893696 cites W2338315908 @default.
• W2071893696 cites W2417758584 @default.
• W2071893696 cites W4233912639 @default.
• W2071893696 cites W4250052351 @default.
• W2071893696 doi "https://doi.org/10.1371/journal.pone.0000946" @default.
• W2071893696 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1978525" @default.
• W2071893696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17895987" @default.
• W2071893696 hasPublicationYear "2007" @default.
• W2071893696 type Work @default.
• W2071893696 sameAs 2071893696 @default.
• W2071893696 citedByCount "59" @default.
• W2071893696 countsByYear W20718936962012 @default.
• W2071893696 countsByYear W20718936962013 @default.
• W2071893696 countsByYear W20718936962014 @default.
• W2071893696 countsByYear W20718936962015 @default.
• W2071893696 countsByYear W20718936962016 @default.
• W2071893696 countsByYear W20718936962017 @default.
• W2071893696 countsByYear W20718936962018 @default.
• W2071893696 countsByYear W20718936962019 @default.
• W2071893696 countsByYear W20718936962020 @default.
• W2071893696 countsByYear W20718936962021 @default.

• next