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- W2071899992 abstract "CCl4, CHCl3 and 1,1-dichloroethylene (EDC) administered to rats resulted in a prompt dose-dependent inhibition of the ATP-dependent calcium pump isolated in the liver microsome fraction. EDC was slightly less potent than CCl4 whereas CHCl3 was approximately one-tenth as potent as CCl4. Because neither EDC nor CHCl3 increased lipid peroxidation in vivo, increased lipid peroxidation does not appear to be a prerequisite for inhibition of the liver-microsome calcium pump. Both CCl4 and EDC have been shown to increase liver calcium early during intoxication, but CHCl3 has been thought to be incapable of increasing liver calcium. Pretreatment with phenobarbital increased the CHCl3 effect of inhibiting the liver-microsome calcium pump and resulted in a several-fold increase of liver calcium levels. CDCl3, which is less hepatotoxic than CHCl3, did not increase liver calcium or inhibit the liver-microsome calcium pump in phenobarbital-pretreated animals. These results suggest that chlorinated hydrocarbons may increase liver calcium as a result of inhibition of a microsomal calcium pump and that this inhibition is associated with the hepatotoxicity of these compounds." @default.
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- W2071899992 date "1980-09-01" @default.
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- W2071899992 title "Inhibition of liver-microsome calcium pump by in vivo administration of CCl4, CHCl3 and 1,1-dichloroethylene (vinylidene chloride)" @default.
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- W2071899992 doi "https://doi.org/10.1016/0006-2952(80)90356-1" @default.
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