FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071903583> ?p ?o ?g. }

• W2071903583 endingPage "72" @default.
• W2071903583 startingPage "69" @default.
• W2071903583 abstract "Burkholderia pseudomallei is a Gram-negative intracellular bacterium and the causative agent of melioidosis. Innate immune mechanisms against this pathogen, which might contribute to outcomes of melioidosis, are little known. We demonstrated here that B. pseudomallei could activate NADPH oxidase in primary human monocytes as judged by production of reactive oxygen species (ROS) and p40(phox) phosphorylation after infection. However, as similar to other intracellular bacteria, this bacterium was able to resist and multiply inside monocytes despite being able to activate NADPH oxidase. In the presence of NADPH oxidase inhibitor, diphenyleneiodonium or apocynin, intracellular multiplication of B. pseudomallei was significantly increased, suggesting that NADPH oxidase-mediated ROS production is essential in suppressing intracellular multiplication of B. pseudomallei. Additionally, interferon-γ (IFN-γ)-mediated intracellular killing of B. pseudomallei requires NADPH oxidase activity, even though ROS level was not detected at higher levels in IFN-γ-treated infected monocytes. Altogether, these results imply that the activation of NADPH plays an essential role in suppressing intracellular multiplication of B. pseudomallei in human monocytes, although this enzyme is not sufficient to stop intracellular multiplication." @default.
• W2071903583 created "2016-06-24" @default.
• W2071903583 creator A5020391003 @default.
• W2071903583 creator A5023174856 @default.
• W2071903583 creator A5030295262 @default.
• W2071903583 creator A5062502707 @default.
• W2071903583 creator A5066156575 @default.
• W2071903583 date "2014-01-22" @default.
• W2071903583 modified "2023-10-17" @default.
• W2071903583 title "Activation of NADPH oxidase is essential, but not sufficient, in controlling intracellular multiplication of<i>Burkholderia pseudomallei</i>in primary human monocytes" @default.
• W2071903583 cites W1586099293 @default.
• W2071903583 cites W1905476191 @default.
• W2071903583 cites W2003824924 @default.
• W2071903583 cites W2016913953 @default.
• W2071903583 cites W2071610506 @default.
• W2071903583 cites W2075986338 @default.
• W2071903583 cites W2081690252 @default.
• W2071903583 cites W2084457694 @default.
• W2071903583 cites W2088630760 @default.
• W2071903583 cites W2088978171 @default.
• W2071903583 cites W2091819001 @default.
• W2071903583 cites W2098694771 @default.
• W2071903583 cites W2102619095 @default.
• W2071903583 cites W2118037244 @default.
• W2071903583 cites W2119864658 @default.
• W2071903583 cites W2120747728 @default.
• W2071903583 cites W2122514721 @default.
• W2071903583 cites W2123063744 @default.
• W2071903583 cites W2126290991 @default.
• W2071903583 cites W2160664483 @default.
• W2071903583 cites W2165731733 @default.
• W2071903583 cites W2169104034 @default.
• W2071903583 cites W2318873727 @default.
• W2071903583 doi "https://doi.org/10.1111/2049-632x.12122" @default.
• W2071903583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24376210" @default.
• W2071903583 hasPublicationYear "2014" @default.
• W2071903583 type Work @default.
• W2071903583 sameAs 2071903583 @default.
• W2071903583 citedByCount "8" @default.
• W2071903583 countsByYear W20719035832015 @default.
• W2071903583 countsByYear W20719035832016 @default.
• W2071903583 countsByYear W20719035832018 @default.
• W2071903583 countsByYear W20719035832019 @default.
• W2071903583 countsByYear W20719035832020 @default.
• W2071903583 countsByYear W20719035832023 @default.
• W2071903583 crossrefType "journal-article" @default.
• W2071903583 hasAuthorship W2071903583A5020391003 @default.
• W2071903583 hasAuthorship W2071903583A5023174856 @default.
• W2071903583 hasAuthorship W2071903583A5030295262 @default.
• W2071903583 hasAuthorship W2071903583A5062502707 @default.
• W2071903583 hasAuthorship W2071903583A5066156575 @default.
• W2071903583 hasBestOaLocation W20719035831 @default.
• W2071903583 hasConcept C153726182 @default.
• W2071903583 hasConcept C181199279 @default.
• W2071903583 hasConcept C2777209548 @default.
• W2071903583 hasConcept C2779110727 @default.
• W2071903583 hasConcept C2779719074 @default.
• W2071903583 hasConcept C2779775996 @default.
• W2071903583 hasConcept C38485361 @default.
• W2071903583 hasConcept C48349386 @default.
• W2071903583 hasConcept C523546767 @default.
• W2071903583 hasConcept C54355233 @default.
• W2071903583 hasConcept C55493867 @default.
• W2071903583 hasConcept C79879829 @default.
• W2071903583 hasConcept C86803240 @default.
• W2071903583 hasConcept C89423630 @default.
• W2071903583 hasConcept C95444343 @default.
• W2071903583 hasConceptScore W2071903583C153726182 @default.
• W2071903583 hasConceptScore W2071903583C181199279 @default.
• W2071903583 hasConceptScore W2071903583C2777209548 @default.
• W2071903583 hasConceptScore W2071903583C2779110727 @default.
• W2071903583 hasConceptScore W2071903583C2779719074 @default.
• W2071903583 hasConceptScore W2071903583C2779775996 @default.
• W2071903583 hasConceptScore W2071903583C38485361 @default.
• W2071903583 hasConceptScore W2071903583C48349386 @default.
• W2071903583 hasConceptScore W2071903583C523546767 @default.
• W2071903583 hasConceptScore W2071903583C54355233 @default.
• W2071903583 hasConceptScore W2071903583C55493867 @default.
• W2071903583 hasConceptScore W2071903583C79879829 @default.
• W2071903583 hasConceptScore W2071903583C86803240 @default.
• W2071903583 hasConceptScore W2071903583C89423630 @default.
• W2071903583 hasConceptScore W2071903583C95444343 @default.
• W2071903583 hasIssue "1" @default.
• W2071903583 hasLocation W20719035831 @default.
• W2071903583 hasLocation W20719035832 @default.
• W2071903583 hasOpenAccess W2071903583 @default.
• W2071903583 hasPrimaryLocation W20719035831 @default.
• W2071903583 hasRelatedWork W1569629748 @default.
• W2071903583 hasRelatedWork W1973953924 @default.
• W2071903583 hasRelatedWork W2011646644 @default.
• W2071903583 hasRelatedWork W2035586817 @default.
• W2071903583 hasRelatedWork W2042687077 @default.
• W2071903583 hasRelatedWork W2043614277 @default.
• W2071903583 hasRelatedWork W2071903583 @default.
• W2071903583 hasRelatedWork W2140441970 @default.
• W2071903583 hasRelatedWork W2417683360 @default.
• W2071903583 hasRelatedWork W2552665963 @default.
• W2071903583 hasVolume "71" @default.

• next