Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071914798> ?p ?o ?g. }
- W2071914798 endingPage "204" @default.
- W2071914798 startingPage "193" @default.
- W2071914798 abstract "447-52D is a human monoclonal antibody isolated from a heterohybridoma derived from an HIV-1-infected individual. This antibody recognizes the hypervariable gp120 V3 loop, and neutralizes both X4 and R5 primary isolates, making it one of the most effective anti-V3 antibodies characterized to date. The crystal structure of the 447-52D Fab in complex with a 16-mer V3 peptide at 2.5 A resolution reveals that the peptide beta hairpin forms a three-stranded mixed beta sheet with complementarity determining region (CDR) H3, with most of the V3 side chains exposed to solvent. Sequence specificity is conferred through interaction of the type-II turn (residues GPGR) at the apex of the V3 hairpin with the base of CDR H3. This novel mode of peptide-antibody recognition enables the antibody to bind to many different V3 sequences where only the GPxR core epitope is absolutely required." @default.
- W2071914798 created "2016-06-24" @default.
- W2071914798 creator A5005010204 @default.
- W2071914798 creator A5010315360 @default.
- W2071914798 creator A5027075998 @default.
- W2071914798 creator A5041332295 @default.
- W2071914798 creator A5066918636 @default.
- W2071914798 date "2004-02-01" @default.
- W2071914798 modified "2023-09-26" @default.
- W2071914798 title "Structural Rationale for the Broad Neutralization of HIV-1 by Human Monoclonal Antibody 447-52D" @default.
- W2071914798 cites W1503866863 @default.
- W2071914798 cites W150399887 @default.
- W2071914798 cites W1539796472 @default.
- W2071914798 cites W1582579447 @default.
- W2071914798 cites W1603139909 @default.
- W2071914798 cites W1821761693 @default.
- W2071914798 cites W1864506204 @default.
- W2071914798 cites W1876598876 @default.
- W2071914798 cites W1967965427 @default.
- W2071914798 cites W1969407832 @default.
- W2071914798 cites W1974261771 @default.
- W2071914798 cites W1975135993 @default.
- W2071914798 cites W1982367245 @default.
- W2071914798 cites W1986736371 @default.
- W2071914798 cites W1988031273 @default.
- W2071914798 cites W1995017064 @default.
- W2071914798 cites W1996024886 @default.
- W2071914798 cites W1999526713 @default.
- W2071914798 cites W2006756069 @default.
- W2071914798 cites W2010521915 @default.
- W2071914798 cites W2010740276 @default.
- W2071914798 cites W2011206581 @default.
- W2071914798 cites W2013917043 @default.
- W2071914798 cites W2014333265 @default.
- W2071914798 cites W2024734109 @default.
- W2071914798 cites W2027720097 @default.
- W2071914798 cites W2028231353 @default.
- W2071914798 cites W2030646603 @default.
- W2071914798 cites W2031571847 @default.
- W2071914798 cites W2034747154 @default.
- W2071914798 cites W2042471904 @default.
- W2071914798 cites W2043530667 @default.
- W2071914798 cites W2044956013 @default.
- W2071914798 cites W2048574795 @default.
- W2071914798 cites W2049563604 @default.
- W2071914798 cites W2051628563 @default.
- W2071914798 cites W2054223443 @default.
- W2071914798 cites W2056564693 @default.
- W2071914798 cites W2067176411 @default.
- W2071914798 cites W2068131424 @default.
- W2071914798 cites W2070146818 @default.
- W2071914798 cites W2070880327 @default.
- W2071914798 cites W2076232874 @default.
- W2071914798 cites W2076584494 @default.
- W2071914798 cites W2078455944 @default.
- W2071914798 cites W2080476827 @default.
- W2071914798 cites W2080528351 @default.
- W2071914798 cites W2083956673 @default.
- W2071914798 cites W2084341498 @default.
- W2071914798 cites W2088403913 @default.
- W2071914798 cites W2092930237 @default.
- W2071914798 cites W2093814303 @default.
- W2071914798 cites W2094967734 @default.
- W2071914798 cites W2096387523 @default.
- W2071914798 cites W2098781795 @default.
- W2071914798 cites W2106315897 @default.
- W2071914798 cites W2106937142 @default.
- W2071914798 cites W2108663264 @default.
- W2071914798 cites W2120279521 @default.
- W2071914798 cites W2121497936 @default.
- W2071914798 cites W2124445678 @default.
- W2071914798 cites W2137966586 @default.
- W2071914798 cites W2143029575 @default.
- W2071914798 cites W2143467722 @default.
- W2071914798 cites W2145462968 @default.
- W2071914798 cites W2146574832 @default.
- W2071914798 cites W2147009832 @default.
- W2071914798 cites W2151124114 @default.
- W2071914798 cites W2151344352 @default.
- W2071914798 cites W2152737925 @default.
- W2071914798 cites W2154728363 @default.
- W2071914798 cites W2166095457 @default.
- W2071914798 cites W2167472144 @default.
- W2071914798 cites W2167795220 @default.
- W2071914798 cites W2172063653 @default.
- W2071914798 cites W2232183823 @default.
- W2071914798 cites W2621219747 @default.
- W2071914798 doi "https://doi.org/10.1016/j.str.2004.01.003" @default.
- W2071914798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14962380" @default.
- W2071914798 hasPublicationYear "2004" @default.
- W2071914798 type Work @default.
- W2071914798 sameAs 2071914798 @default.
- W2071914798 citedByCount "179" @default.
- W2071914798 countsByYear W20719147982012 @default.
- W2071914798 countsByYear W20719147982013 @default.
- W2071914798 countsByYear W20719147982014 @default.
- W2071914798 countsByYear W20719147982015 @default.
- W2071914798 countsByYear W20719147982016 @default.