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- W2071914973 abstract "Microtubule dynamics facilitate neurite growth and establish morphology, but the role of minus-end binding proteins in these processes is largely unexplored. CAMSAP homologs associate with microtubule minus-ends, and are important for the stability of epithelial cell adhesions. In this study, we report morphological defects in neurons and neuromuscular defects in mutants of the C. elegans CAMSAP, ptrn-1. Mechanosensory neurons initially extend wild-type neurites, and subsequently remodel by overextending neurites and retracting synaptic branches and presynaptic varicosities. This neuronal remodeling can be activated by mutations known to alter microtubules, and depends on a functioning DLK-1 MAP kinase pathway. We found that PTRN-1 localizes to both neurites and synapses, and our results suggest that alterations of microtubule structures caused by loss of PTRN-1 function activates a remodeling program leading to changes in neurite morphology. We propose a model whereby minus-end microtubule stabilization mediated by a functional PTRN-1 is necessary for morphological maintenance of neurons." @default.
- W2071914973 created "2016-06-24" @default.
- W2071914973 creator A5020846782 @default.
- W2071914973 creator A5069577638 @default.
- W2071914973 creator A5082593602 @default.
- W2071914973 date "2014-02-25" @default.
- W2071914973 modified "2023-09-23" @default.
- W2071914973 title "The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites" @default.
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- W2071914973 doi "https://doi.org/10.7554/elife.01637" @default.
- W2071914973 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3930908" @default.
- W2071914973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24569480" @default.
- W2071914973 hasPublicationYear "2014" @default.
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