FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071916629> ?p ?o ?g. }

• W2071916629 endingPage "6239" @default.
• W2071916629 startingPage "6236" @default.
• W2071916629 abstract "The ALL-1 gene, located on chromosome band 11q23, is fused to a variety of other genes by reciprocal chromosomal translocations present in 5-10% of human acute leukemias. We have recently reported the detection by Southern blot of ALL-1 gene rearrangements in adult patients with acute myeloid leukemia lacking cytogenetic evidence of 11q23 translocations. These include 2 of 19 patients with normal karyotypes as well as 3 of 4 patients with trisomy 11. To characterize the abnormal ALL-1 genes, we cloned the ALL-1 rearrangements from two patients with trisomy 11. Characterization of the clones, together with Southern blot analysis, indicates that the ALL-1 rearrangement in both patients is the result of a direct tandem duplication of a portion of the ALL-1 gene spanning exons 2-6. The partial ALL-1 duplication is also detected by Southern blot analysis in a patient with a normal karyotype. RNA PCR and DNA sequence analysis show that the partially duplicated ALL-1 gene is transcribed into mRNA capable of encoding a partially duplicated protein. Partial duplication of ALL-1, in which a portion of a putative protooncogene is fused with itself, represents an additional genetic mechanism for leukemogenesis. Our findings suggest that the presence of trisomy in malignancy may sometimes indicate the partial duplication of a cellular protooncogene." @default.
• W2071916629 created "2016-06-24" @default.
• W2071916629 creator A5000768230 @default.
• W2071916629 creator A5004671795 @default.
• W2071916629 creator A5007969061 @default.
• W2071916629 creator A5035250536 @default.
• W2071916629 creator A5049192022 @default.
• W2071916629 creator A5050031787 @default.
• W2071916629 creator A5079700663 @default.
• W2071916629 date "1994-06-21" @default.
• W2071916629 modified "2023-10-16" @default.
• W2071916629 title "ALL-1 partial duplication in acute leukemia." @default.
• W2071916629 cites W1529947401 @default.
• W2071916629 cites W1565552070 @default.
• W2071916629 cites W1830573358 @default.
• W2071916629 cites W1866691507 @default.
• W2071916629 cites W1976439451 @default.
• W2071916629 cites W1979652116 @default.
• W2071916629 cites W1982640053 @default.
• W2071916629 cites W2009310436 @default.
• W2071916629 cites W2034081121 @default.
• W2071916629 cites W2036296056 @default.
• W2071916629 cites W2040464173 @default.
• W2071916629 cites W2051296872 @default.
• W2071916629 cites W2079604568 @default.
• W2071916629 cites W2095184701 @default.
• W2071916629 cites W2106188260 @default.
• W2071916629 cites W2112087352 @default.
• W2071916629 cites W2151091321 @default.
• W2071916629 cites W2157426939 @default.
• W2071916629 cites W2162328608 @default.
• W2071916629 cites W300009126 @default.
• W2071916629 doi "https://doi.org/10.1073/pnas.91.13.6236" @default.
• W2071916629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/44173" @default.
• W2071916629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8016145" @default.
• W2071916629 hasPublicationYear "1994" @default.
• W2071916629 type Work @default.
• W2071916629 sameAs 2071916629 @default.
• W2071916629 citedByCount "206" @default.
• W2071916629 countsByYear W20719166292012 @default.
• W2071916629 countsByYear W20719166292013 @default.
• W2071916629 countsByYear W20719166292014 @default.
• W2071916629 countsByYear W20719166292015 @default.
• W2071916629 countsByYear W20719166292016 @default.
• W2071916629 countsByYear W20719166292017 @default.
• W2071916629 countsByYear W20719166292018 @default.
• W2071916629 countsByYear W20719166292019 @default.
• W2071916629 countsByYear W20719166292020 @default.
• W2071916629 countsByYear W20719166292021 @default.
• W2071916629 countsByYear W20719166292022 @default.
• W2071916629 countsByYear W20719166292023 @default.
• W2071916629 crossrefType "journal-article" @default.
• W2071916629 hasAuthorship W2071916629A5000768230 @default.
• W2071916629 hasAuthorship W2071916629A5004671795 @default.
• W2071916629 hasAuthorship W2071916629A5007969061 @default.
• W2071916629 hasAuthorship W2071916629A5035250536 @default.
• W2071916629 hasAuthorship W2071916629A5049192022 @default.
• W2071916629 hasAuthorship W2071916629A5050031787 @default.
• W2071916629 hasAuthorship W2071916629A5079700663 @default.
• W2071916629 hasBestOaLocation W20719166291 @default.
• W2071916629 hasConcept C104317684 @default.
• W2071916629 hasConcept C133307689 @default.
• W2071916629 hasConcept C138626823 @default.
• W2071916629 hasConcept C153911025 @default.
• W2071916629 hasConcept C156446351 @default.
• W2071916629 hasConcept C2992511266 @default.
• W2071916629 hasConcept C30481170 @default.
• W2071916629 hasConcept C53226629 @default.
• W2071916629 hasConcept C54355233 @default.
• W2071916629 hasConcept C7602840 @default.
• W2071916629 hasConcept C86803240 @default.
• W2071916629 hasConceptScore W2071916629C104317684 @default.
• W2071916629 hasConceptScore W2071916629C133307689 @default.
• W2071916629 hasConceptScore W2071916629C138626823 @default.
• W2071916629 hasConceptScore W2071916629C153911025 @default.
• W2071916629 hasConceptScore W2071916629C156446351 @default.
• W2071916629 hasConceptScore W2071916629C2992511266 @default.
• W2071916629 hasConceptScore W2071916629C30481170 @default.
• W2071916629 hasConceptScore W2071916629C53226629 @default.
• W2071916629 hasConceptScore W2071916629C54355233 @default.
• W2071916629 hasConceptScore W2071916629C7602840 @default.
• W2071916629 hasConceptScore W2071916629C86803240 @default.
• W2071916629 hasIssue "13" @default.
• W2071916629 hasLocation W20719166291 @default.
• W2071916629 hasLocation W20719166292 @default.
• W2071916629 hasLocation W20719166293 @default.
• W2071916629 hasLocation W20719166294 @default.
• W2071916629 hasOpenAccess W2071916629 @default.
• W2071916629 hasPrimaryLocation W20719166291 @default.
• W2071916629 hasRelatedWork W1970446973 @default.
• W2071916629 hasRelatedWork W2040427754 @default.
• W2071916629 hasRelatedWork W2052126024 @default.
• W2071916629 hasRelatedWork W2053757086 @default.
• W2071916629 hasRelatedWork W2053965973 @default.
• W2071916629 hasRelatedWork W2071916629 @default.
• W2071916629 hasRelatedWork W2088284756 @default.
• W2071916629 hasRelatedWork W2111147256 @default.
• W2071916629 hasRelatedWork W2412952278 @default.

• next