Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071917584> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2071917584 endingPage "62" @default.
- W2071917584 startingPage "59" @default.
- W2071917584 abstract "Almost uniquely in pharmacology, drug safety assessment is driven by the need for elaboration and validation of methods for detecting drug actions. This is the 9th consecutive year that the Journal of Pharmacological and Toxicological Methods (JPTM) has published themed issues arising from the annual meeting of the Safety Pharmacology Society (SPS). The SPS is now past its 10th year as a distinct (from pharmacology to toxicology) discipline that integrates safety pharmacologists from industry with those in academia and the various global regulatory authorities. The themes of the 2011 meeting were (i) the bridging of safety assessment of a new chemical entity (NCE) between all the parties involved, (ii) applied technologies and (iii) translation. This issue of JPTM reflects these themes. The content is informed by the regulatory guidance documents (S7A and S7B) that apply prior to first in human (FIH) studies, which emphasize the importance of seeking model validation. The manuscripts encompass a broad spectrum of safety pharmacology topics including application of state-of-the-art techniques for study conduct and data processing and evaluation. This includes some exciting novel integrated core battery study designs, refinements in hemodynamic assessment, arrhythmia analysis algorithms, and additionally an overview of safety immunopharmacology, and a brief survey discussing similarities and differences in business models that pharmaceutical companies employ in safety pharmacology, together with SPS recommendations on 'best practice' for the conduct of a non-clinical cardiovascular assessment of a NCE." @default.
- W2071917584 created "2016-06-24" @default.
- W2071917584 creator A5061517390 @default.
- W2071917584 creator A5081274926 @default.
- W2071917584 date "2012-09-01" @default.
- W2071917584 modified "2023-09-27" @default.
- W2071917584 title "Methodological innovations expand the safety pharmacology horizon" @default.
- W2071917584 cites W1541741485 @default.
- W2071917584 cites W162464147 @default.
- W2071917584 cites W1967348830 @default.
- W2071917584 cites W1976023072 @default.
- W2071917584 cites W1986856154 @default.
- W2071917584 cites W1996212925 @default.
- W2071917584 cites W2000081466 @default.
- W2071917584 cites W2004226501 @default.
- W2071917584 cites W2009052610 @default.
- W2071917584 cites W2022786689 @default.
- W2071917584 cites W2051009078 @default.
- W2071917584 cites W2052824454 @default.
- W2071917584 cites W2053359053 @default.
- W2071917584 cites W2061616701 @default.
- W2071917584 cites W2081706813 @default.
- W2071917584 cites W2082297439 @default.
- W2071917584 cites W2092669992 @default.
- W2071917584 cites W2108375254 @default.
- W2071917584 cites W2125308417 @default.
- W2071917584 cites W2131472696 @default.
- W2071917584 cites W2132647209 @default.
- W2071917584 cites W2133488495 @default.
- W2071917584 cites W2147428024 @default.
- W2071917584 cites W2152533263 @default.
- W2071917584 cites W2171887903 @default.
- W2071917584 cites W4245202357 @default.
- W2071917584 doi "https://doi.org/10.1016/j.vascn.2012.05.004" @default.
- W2071917584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22617368" @default.
- W2071917584 hasPublicationYear "2012" @default.
- W2071917584 type Work @default.
- W2071917584 sameAs 2071917584 @default.
- W2071917584 citedByCount "8" @default.
- W2071917584 countsByYear W20719175842013 @default.
- W2071917584 countsByYear W20719175842014 @default.
- W2071917584 countsByYear W20719175842015 @default.
- W2071917584 countsByYear W20719175842018 @default.
- W2071917584 countsByYear W20719175842020 @default.
- W2071917584 countsByYear W20719175842023 @default.
- W2071917584 crossrefType "journal-article" @default.
- W2071917584 hasAuthorship W2071917584A5061517390 @default.
- W2071917584 hasAuthorship W2071917584A5081274926 @default.
- W2071917584 hasConcept C106436119 @default.
- W2071917584 hasConcept C127413603 @default.
- W2071917584 hasConcept C142724271 @default.
- W2071917584 hasConcept C185592680 @default.
- W2071917584 hasConcept C21951064 @default.
- W2071917584 hasConcept C2776190711 @default.
- W2071917584 hasConcept C2778618615 @default.
- W2071917584 hasConcept C2780035454 @default.
- W2071917584 hasConcept C2781050149 @default.
- W2071917584 hasConcept C3020442560 @default.
- W2071917584 hasConcept C539667460 @default.
- W2071917584 hasConcept C55587333 @default.
- W2071917584 hasConcept C63433958 @default.
- W2071917584 hasConcept C71924100 @default.
- W2071917584 hasConcept C98274493 @default.
- W2071917584 hasConceptScore W2071917584C106436119 @default.
- W2071917584 hasConceptScore W2071917584C127413603 @default.
- W2071917584 hasConceptScore W2071917584C142724271 @default.
- W2071917584 hasConceptScore W2071917584C185592680 @default.
- W2071917584 hasConceptScore W2071917584C21951064 @default.
- W2071917584 hasConceptScore W2071917584C2776190711 @default.
- W2071917584 hasConceptScore W2071917584C2778618615 @default.
- W2071917584 hasConceptScore W2071917584C2780035454 @default.
- W2071917584 hasConceptScore W2071917584C2781050149 @default.
- W2071917584 hasConceptScore W2071917584C3020442560 @default.
- W2071917584 hasConceptScore W2071917584C539667460 @default.
- W2071917584 hasConceptScore W2071917584C55587333 @default.
- W2071917584 hasConceptScore W2071917584C63433958 @default.
- W2071917584 hasConceptScore W2071917584C71924100 @default.
- W2071917584 hasConceptScore W2071917584C98274493 @default.
- W2071917584 hasIssue "2" @default.
- W2071917584 hasLocation W20719175841 @default.
- W2071917584 hasLocation W20719175842 @default.
- W2071917584 hasOpenAccess W2071917584 @default.
- W2071917584 hasPrimaryLocation W20719175841 @default.
- W2071917584 hasRelatedWork W1603416295 @default.
- W2071917584 hasRelatedWork W188266097 @default.
- W2071917584 hasRelatedWork W2001008384 @default.
- W2071917584 hasRelatedWork W2039367290 @default.
- W2071917584 hasRelatedWork W2055397218 @default.
- W2071917584 hasRelatedWork W2076120318 @default.
- W2071917584 hasRelatedWork W211573666 @default.
- W2071917584 hasRelatedWork W2314307463 @default.
- W2071917584 hasRelatedWork W2358609441 @default.
- W2071917584 hasRelatedWork W4214543767 @default.
- W2071917584 hasVolume "66" @default.
- W2071917584 isParatext "false" @default.
- W2071917584 isRetracted "false" @default.
- W2071917584 magId "2071917584" @default.
- W2071917584 workType "article" @default.