FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071923881> ?p ?o ?g. }

• W2071923881 endingPage "236" @default.
• W2071923881 startingPage "229" @default.
• W2071923881 abstract "The 5-HT3 receptor antagonists zacopride and GR38032F are highly effective inhibitors of emesis induced by ionizing radiation and chemotherapeutic drugs such as cisplatin. The present study evaluated zacopride and GR38032F for efficacy in inhibiting the formation of the conditioned taste aversion (CTA) induced by cisplatin or lithium chloride in rats. The glucocorticoid dexamethasone, which has been reported to be effective against both the emetic and CTA-inducing effects of cisplatin, was included as a reference compound. When administered alone by i.p. injection, zacopride (0.1-10 mg/kg), GR38032F (10 mg/kg) and cisplatin (0.32-1.8 mg/kg) induced a CTA to an 0.1% saccharin solution; lower doses of each compound were ineffective. When administered as a pretreatment, neither zacopride (0.001-0.1 mg/kg) nor GR38032F (0.01-10 mg/kg) attenuated the CTA induced by cisplatin (0.32 and 0.56 mg/kg) or lithium chloride (10 mg/kg). In contrast, dexamethasone (0.32 and 1.0 mg/kg) attenuated the CTA induced by 0.32 but not 0.56 mg/kg of cisplatin. In an attempt to evaluate higher doses of zacopride against cisplatin without the potentially confounding factor that these doses by themselves induce a CTA, rats were injected with zacopride on three separate days prior to the aversion conditioning session. This pre-exposure treatment blocked the formation of the zacopride-induced CTA, but did not improve the efficacy of zacopride in attenuating the cisplatin-induced CTA. These results suggest that neither the cisplatin- nor the lithium-induced CTA in rats are due to effects that are sensitive to 5-HT3 receptor blockade." @default.
• W2071923881 created "2016-06-24" @default.
• W2071923881 creator A5024352303 @default.
• W2071923881 creator A5025533629 @default.
• W2071923881 creator A5056875177 @default.
• W2071923881 creator A5065346205 @default.
• W2071923881 date "1992-08-01" @default.
• W2071923881 modified "2023-10-12" @default.
• W2071923881 title "Cisplatin-induced conditioned taste aversion: attenuation by dexamethasone but not zacopride or GR38032F" @default.
• W2071923881 cites W1976557660 @default.
• W2071923881 cites W1991721231 @default.
• W2071923881 cites W1997327345 @default.
• W2071923881 cites W1997357590 @default.
• W2071923881 cites W1998519352 @default.
• W2071923881 cites W2008521236 @default.
• W2071923881 cites W2010163969 @default.
• W2071923881 cites W2010530669 @default.
• W2071923881 cites W2015467180 @default.
• W2071923881 cites W2017673970 @default.
• W2071923881 cites W2018631222 @default.
• W2071923881 cites W2019012629 @default.
• W2071923881 cites W2023688453 @default.
• W2071923881 cites W2028359086 @default.
• W2071923881 cites W2038671475 @default.
• W2071923881 cites W2041416021 @default.
• W2071923881 cites W2043568662 @default.
• W2071923881 cites W2053188801 @default.
• W2071923881 cites W2056244921 @default.
• W2071923881 cites W2059961390 @default.
• W2071923881 cites W2067206847 @default.
• W2071923881 cites W2069284352 @default.
• W2071923881 cites W2069494748 @default.
• W2071923881 cites W2078898260 @default.
• W2071923881 cites W2083278955 @default.
• W2071923881 cites W2085866328 @default.
• W2071923881 cites W2090240180 @default.
• W2071923881 cites W2127616214 @default.
• W2071923881 cites W2133144591 @default.
• W2071923881 cites W4247792491 @default.
• W2071923881 doi "https://doi.org/10.1016/0014-2999(92)90173-2" @default.
• W2071923881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1330594" @default.
• W2071923881 hasPublicationYear "1992" @default.
• W2071923881 type Work @default.
• W2071923881 sameAs 2071923881 @default.
• W2071923881 citedByCount "30" @default.
• W2071923881 countsByYear W20719238812012 @default.
• W2071923881 countsByYear W20719238812014 @default.
• W2071923881 countsByYear W20719238812015 @default.
• W2071923881 countsByYear W20719238812016 @default.
• W2071923881 countsByYear W20719238812017 @default.
• W2071923881 countsByYear W20719238812020 @default.
• W2071923881 countsByYear W20719238812023 @default.
• W2071923881 crossrefType "journal-article" @default.
• W2071923881 hasAuthorship W2071923881A5024352303 @default.
• W2071923881 hasAuthorship W2071923881A5025533629 @default.
• W2071923881 hasAuthorship W2071923881A5056875177 @default.
• W2071923881 hasAuthorship W2071923881A5065346205 @default.
• W2071923881 hasConcept C126322002 @default.
• W2071923881 hasConcept C134018914 @default.
• W2071923881 hasConcept C164742699 @default.
• W2071923881 hasConcept C185592680 @default.
• W2071923881 hasConcept C2776694085 @default.
• W2071923881 hasConcept C2778239845 @default.
• W2071923881 hasConcept C2780401358 @default.
• W2071923881 hasConcept C55493867 @default.
• W2071923881 hasConcept C71924100 @default.
• W2071923881 hasConcept C8868529 @default.
• W2071923881 hasConcept C98274493 @default.
• W2071923881 hasConceptScore W2071923881C126322002 @default.
• W2071923881 hasConceptScore W2071923881C134018914 @default.
• W2071923881 hasConceptScore W2071923881C164742699 @default.
• W2071923881 hasConceptScore W2071923881C185592680 @default.
• W2071923881 hasConceptScore W2071923881C2776694085 @default.
• W2071923881 hasConceptScore W2071923881C2778239845 @default.
• W2071923881 hasConceptScore W2071923881C2780401358 @default.
• W2071923881 hasConceptScore W2071923881C55493867 @default.
• W2071923881 hasConceptScore W2071923881C71924100 @default.
• W2071923881 hasConceptScore W2071923881C8868529 @default.
• W2071923881 hasConceptScore W2071923881C98274493 @default.
• W2071923881 hasIssue "2-3" @default.
• W2071923881 hasLocation W20719238811 @default.
• W2071923881 hasLocation W20719238812 @default.
• W2071923881 hasOpenAccess W2071923881 @default.
• W2071923881 hasPrimaryLocation W20719238811 @default.
• W2071923881 hasRelatedWork W1995335629 @default.
• W2071923881 hasRelatedWork W2017504295 @default.
• W2071923881 hasRelatedWork W2091461259 @default.
• W2071923881 hasRelatedWork W2149068418 @default.
• W2071923881 hasRelatedWork W2406596433 @default.
• W2071923881 hasRelatedWork W2406608798 @default.
• W2071923881 hasRelatedWork W2460036924 @default.
• W2071923881 hasRelatedWork W2748952813 @default.
• W2071923881 hasRelatedWork W3120025342 @default.
• W2071923881 hasRelatedWork W3215212400 @default.
• W2071923881 hasVolume "218" @default.
• W2071923881 isParatext "false" @default.
• W2071923881 isRetracted "false" @default.
• W2071923881 magId "2071923881" @default.

• next