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- W2071938912 abstract "Abnormal activation of the Wnt/β-catenin pathway and subsequent up-regulation of β-catenin response transcription (CRT) are associated with the development of colon cancer. Thus, the Wnt/β-catenin pathway is an attractive target for chemoprevention and treatment of this cancer. We used a cell-based screen to identify a methanol extract of Polysiphonia japonica (EPJ) that suppresses the Wnt/β-catenin pathway without altering the level of β-catenin protein and reduces the expression of cyclin D1, which is a known β-catenin/T cell factor (TCF)-dependent gene. EPJ inhibited the growth of various colon cancer cells. In addition, EPJ induced the nuclear translocation of nuclear factor-κB (NF-κB) in SW480 colon cancer cells. Our findings suggest that EPJ attenuates Wnt/β-catenin signaling via activation of NF-κB and can potentially be used as a chemopreventive agent against colon cancer." @default.
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- W2071938912 date "2006-06-01" @default.
- W2071938912 modified "2023-09-27" @default.
- W2071938912 title "Polysiphonia japonica extract suppresses the Wnt/β-catenin pathway in colon cancer cells by activation of NF-κB" @default.
- W2071938912 doi "https://doi.org/10.3892/ijmm.17.6.1005" @default.
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