FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071944769> ?p ?o ?g. }

• W2071944769 endingPage "15932" @default.
• W2071944769 startingPage "15923" @default.
• W2071944769 abstract "Collagen is the most abundant protein in animals. The protein consists of a helix of three strands, each with sequence X−Y−Gly. Natural collagen is most stable when X is (2S)-proline (Pro) and Y is (2S,4R)-4-hydroxyproline (4R-Hyp). We had shown previously that triple helices in which X is (2S,4S)-4-fluoroproline (4S-Flp) or Y is (2S,4R)-4-fluoroproline (4R-Flp) display hyperstability. This hyperstability arises from stereoelectronic effects that preorganize the main-chain dihedral angles in the conformation found in the triple helix. Here, we report the synthesis of strands containing both 4S-Flp in the X-position and 4R-Flp in the Y-position. We find that these strands do not form a stable triple helix, presumably because of an unfavorable steric interaction between fluoro groups on adjacent strands. Density functional theory calculations indicate that (2S,3S)-3-fluoroproline (3S-Flp), like 4S-Flp, should preorganize the main chain properly for triple-helix formation but without a steric conflict. Synthetic strands containing 3S-Flp in the X-position and 4R-Flp in the Y-position do form a triple helix. This helix is, however, less stable than one with Pro in the X-position, presumably because of an unfavorable inductive effect that diminishes the strength of the interstrand 3S-FlpCO···HNGly hydrogen bond. Thus, other forces can counter the benefits derived from the proper preorganization. Although (Pro−Pro−Gly)7 and (4S-Flp−4R-Flp−Gly)7 do not form stable homotrimeric helices, mixtures of these two peptides form stable heterotrimeric helices containing one (Pro−Pro−Gly)7 strand and two (4S-Flp−4R-Flp−Gly)7 strands. This stoichiometry can be understood by considering the cross sections of the two possible heterotrimeric helices. This unexpected finding portends the development of a “code” for the self-assembly of determinate triple helices from two or three strands." @default.
• W2071944769 created "2016-06-24" @default.
• W2071944769 creator A5019213891 @default.
• W2071944769 creator A5041841384 @default.
• W2071944769 date "2005-10-19" @default.
• W2071944769 modified "2023-10-02" @default.
• W2071944769 title "Stereoelectronic and Steric Effects in the Collagen Triple Helix: Toward a Code for Strand Association" @default.
• W2071944769 cites W1645361893 @default.
• W2071944769 cites W1964556609 @default.
• W2071944769 cites W1967550539 @default.
• W2071944769 cites W1968983628 @default.
• W2071944769 cites W1970087440 @default.
• W2071944769 cites W1971763423 @default.
• W2071944769 cites W1974049559 @default.
• W2071944769 cites W1976144128 @default.
• W2071944769 cites W1979221090 @default.
• W2071944769 cites W1987787552 @default.
• W2071944769 cites W1988757615 @default.
• W2071944769 cites W1991820906 @default.
• W2071944769 cites W1993032194 @default.
• W2071944769 cites W2002656822 @default.
• W2071944769 cites W2007772637 @default.
• W2071944769 cites W2021798993 @default.
• W2071944769 cites W2032319199 @default.
• W2071944769 cites W2039130480 @default.
• W2071944769 cites W2046019764 @default.
• W2071944769 cites W2050185766 @default.
• W2071944769 cites W2061722950 @default.
• W2071944769 cites W2062959560 @default.
• W2071944769 cites W2068118841 @default.
• W2071944769 cites W2078895436 @default.
• W2071944769 cites W2087931197 @default.
• W2071944769 cites W2110100379 @default.
• W2071944769 cites W2120596997 @default.
• W2071944769 cites W2330772790 @default.
• W2071944769 cites W2485071058 @default.
• W2071944769 cites W2616798345 @default.
• W2071944769 doi "https://doi.org/10.1021/ja054674r" @default.
• W2071944769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16277536" @default.
• W2071944769 hasPublicationYear "2005" @default.
• W2071944769 type Work @default.
• W2071944769 sameAs 2071944769 @default.
• W2071944769 citedByCount "131" @default.
• W2071944769 countsByYear W20719447692012 @default.
• W2071944769 countsByYear W20719447692013 @default.
• W2071944769 countsByYear W20719447692014 @default.
• W2071944769 countsByYear W20719447692015 @default.
• W2071944769 countsByYear W20719447692016 @default.
• W2071944769 countsByYear W20719447692017 @default.
• W2071944769 countsByYear W20719447692018 @default.
• W2071944769 countsByYear W20719447692019 @default.
• W2071944769 countsByYear W20719447692020 @default.
• W2071944769 countsByYear W20719447692021 @default.
• W2071944769 countsByYear W20719447692022 @default.
• W2071944769 countsByYear W20719447692023 @default.
• W2071944769 crossrefType "journal-article" @default.
• W2071944769 hasAuthorship W2071944769A5019213891 @default.
• W2071944769 hasAuthorship W2071944769A5041841384 @default.
• W2071944769 hasConcept C10919887 @default.
• W2071944769 hasConcept C112887158 @default.
• W2071944769 hasConcept C155181932 @default.
• W2071944769 hasConcept C178790620 @default.
• W2071944769 hasConcept C185592680 @default.
• W2071944769 hasConcept C188027245 @default.
• W2071944769 hasConcept C18903297 @default.
• W2071944769 hasConcept C196099240 @default.
• W2071944769 hasConcept C201194858 @default.
• W2071944769 hasConcept C204921945 @default.
• W2071944769 hasConcept C2778530040 @default.
• W2071944769 hasConcept C2779965526 @default.
• W2071944769 hasConcept C32909587 @default.
• W2071944769 hasConcept C521977710 @default.
• W2071944769 hasConcept C68381374 @default.
• W2071944769 hasConcept C71240020 @default.
• W2071944769 hasConcept C8010536 @default.
• W2071944769 hasConcept C86803240 @default.
• W2071944769 hasConcept C89025888 @default.
• W2071944769 hasConceptScore W2071944769C10919887 @default.
• W2071944769 hasConceptScore W2071944769C112887158 @default.
• W2071944769 hasConceptScore W2071944769C155181932 @default.
• W2071944769 hasConceptScore W2071944769C178790620 @default.
• W2071944769 hasConceptScore W2071944769C185592680 @default.
• W2071944769 hasConceptScore W2071944769C188027245 @default.
• W2071944769 hasConceptScore W2071944769C18903297 @default.
• W2071944769 hasConceptScore W2071944769C196099240 @default.
• W2071944769 hasConceptScore W2071944769C201194858 @default.
• W2071944769 hasConceptScore W2071944769C204921945 @default.
• W2071944769 hasConceptScore W2071944769C2778530040 @default.
• W2071944769 hasConceptScore W2071944769C2779965526 @default.
• W2071944769 hasConceptScore W2071944769C32909587 @default.
• W2071944769 hasConceptScore W2071944769C521977710 @default.
• W2071944769 hasConceptScore W2071944769C68381374 @default.
• W2071944769 hasConceptScore W2071944769C71240020 @default.
• W2071944769 hasConceptScore W2071944769C8010536 @default.
• W2071944769 hasConceptScore W2071944769C86803240 @default.
• W2071944769 hasConceptScore W2071944769C89025888 @default.
• W2071944769 hasIssue "45" @default.
• W2071944769 hasLocation W20719447691 @default.

• next