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- W2071976931 abstract "We explored by ESR the potential of 2'-deoxy-oligonucleotides as biocompatible inhibitors of the Fe(II)/Cu(I)/(II)-induced *OH formation from H(2)O(2). d(A)(5), (2'-OMe-A)(5), d(A)(7), d(A)(20), and d(T)(20), proved highly potent antioxidants (IC(50): 5-17 or 48-85 microM in inhibiting Fe(II)/Cu(I)- or Cu(II)-induced H(2)O(2)- decomposition), representing 40 to 215 - fold increase of potency as compared to Trolox. The antioxidant activity does not depend on the oligonucleotides' length or composition. The primary inhibition mechanism by oligonucleotides is metal-ion chelation and the secondary is radical scavenging. (1)H-, (31)P-NMR and ESR data suggest that Cu coordination involves adenine bases and 1-2 phosphates. We propose the use of short, metabolically stable oligonucleotides as highly potent and long-lived (t(1/2) ca. 20 h) antioxidants that may prevent oxidative damage." @default.
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- W2071976931 date "2008-09-01" @default.
- W2071976931 modified "2023-09-26" @default.
- W2071976931 title "OLIGONUCLEOTIDES ARE POTENT ANTIOXIDANTS ACTING MAINLY AS METAL-ION CHELATORS" @default.
- W2071976931 doi "https://doi.org/10.1093/nass/nrn246" @default.
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