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- W2071979967 abstract "The synthesis of individual proteins in the mouse plasmacytoma cell MPC-11 is differentially inhibited when the rate of polypeptide chain initiation is reduced by exposure of cells to hypertonic medium. The synthesis of immunoglobulin G light and heavy chain polypeptides is 3.5 to 4-fold and 1.5 to 2-fold more resistant, respectively, than the synthesis of non-immunoglobulin G proteins when total protein synthesis is reduced by ~90%. In contrast, when polypeptide chain elongation is inhibited, the synthesis of the light and heavy chains is not more resistant than the synthesis of non-immunoglobulin G proteins. The results with MPC-11 cells suggests that: (1) under standard growth conditions the relative synthesis of individual proteins is determined mainly, but not exclusively, by the relative amounts of the individual messenger RNA species present in the cell; (2) under conditions where the overall rate of polypeptide chain initiation is reduced the relative synthesis of individual proteins becomes more dependent upon the intrinsic ability of their corresponding mRNAs to form functional mRNA-ribosome initiation complexes." @default.
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- W2071979967 date "1976-04-01" @default.
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- W2071979967 title "Variation in the relative synthesis of immunoglobulin G and non-immunoglobulin G proteins in cultured MPC-11 cells with changes in the overall rate of polypeptide chain initiation and elongation" @default.
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- W2071979967 doi "https://doi.org/10.1016/0022-2836(76)90337-5" @default.
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