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• W2071987689 abstract "The metabolism of amyloid precursor protein (APP) is central to Alzheimer's disease pathogenesis. Recent data have linked APP and presenilin to the Wnt/wingless signaling pathway. To assess affects of Wnt stimulation on APP isoform expression, we infected PC12 cells and C57MG cells with a retrovirus containing murine Wnt-1. In PC12 cells, Wnt-1 expression is associated with induction of exon 15 deletion from APP mRNA and expression of L-APP. Our data suggest that APP isoform expression is regulated, in part, by the Wnt/wingless signaling pathway." @default.
• W2071987689 created "2016-06-24" @default.
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• W2071987689 date "2004-06-01" @default.
• W2071987689 modified "2023-09-26" @default.
• W2071987689 title "Wnt-1 expression in PC12 cells induces exon 15 deletion and expression of L-APP" @default.
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• W2071987689 doi "https://doi.org/10.1016/j.nbd.2004.01.004" @default.
• W2071987689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15207262" @default.
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