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• W2071993071 abstract "Two new sesquiterpene coumarins, designated 5′-acetoxy-8′-hydroxyumbelliprenin (1) and 10′R-acetoxy-11′-hydroxyumbelliprenin (2), and a new diterpene, 15-hydroxy-6-en-dehydroabietic acid (3), along with 27 known compounds, were isolated from a CHCl3-soluble extract of Ferula assa-foetida through bioassay-guided fractionation. The structures of the new metabolites 1−3 were identified by spectroscopic data interpretation and by the Mosher ester method. Compounds 4 and 6−13 showed greater potency against influenza A virus (H1N1) (IC50 0.26−0.86 μg/mL) than amantadine (IC50 0.92 μg/mL), and 11 exhibited the best potency (IC50 0.51, 2.6, and 3.4 μg/mL) of these compounds against the HepG2, Hep3B, and MCF-7 cancer cell lines, respectively." @default.
• W2071993071 created "2016-06-24" @default.
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• W2071993071 date "2009-08-19" @default.
• W2071993071 modified "2023-10-01" @default.
• W2071993071 title "Influenza A (H₁N₁) Antiviral and Cytotoxic Agents from <i>Ferula assa-foetida</i>" @default.
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• W2071993071 doi "https://doi.org/10.1021/np900158f" @default.
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