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• W2072000132 abstract "Context: Potentilla mooniana Wight. (Rosaceae) is a plant found in the Himalayan region where the root is traditionally used to treat stomach problems including gastric-ulcer.Objective: To scientifically validate the gastro-protective effect and derive the possible mechanistic activity of the ethanol root extract from P. mooniana (EPM).Materials and methods: The gastroprotective effect of EPM (100–400 mg/kg, p.o.) was evaluated on both the physical (Pyloric ligation, PL; Cold restrain stress, CRS) and chemical (absolute ethanol, EtOH; aspirin, ASP) ulcerogens induced ulceration in rats. The mechanistic activity of EPM was tested on various gastric-ulcer parameters, namely gastric pH, volume, acid–pepsin output, DNA content, histamine level, H+K+–ATPase activity, mucus content, microvascular permeability, antioxidant markers, and gastric-histopathological study.Results: EPM significantly reduces the ulcer score against all the four tested gastric-ulcer models. In the PL model, EPM showed significant reduction (p < 0.05) in acid–pepsin output and cell shedding; however, no significant effect was observed on gastric volume, cell proliferation, stomach glandular weight, and histamine levels. EPM (400 mg/kg, p.o.) when compared with ulcer control showed significant increase in gastric pH by 41.6% and decrease in H+K+–ATPase activity by 47.73%. In addition, EPM showed significant increase in mucus content by 58.60% and a decrease in the microvascular permeability of Evans Blue by 85.00%, justifying its protective effects. Furthermore, EPM also showed significant antioxidant activity and histopathologically possessed excellent cytoprotective effect.Conclusion: The gastro-protective effect of EPM is attributed mainly to the defensive mechanism owing to the presence of a good quantity of polyphenolic components." @default.
• W2072000132 created "2016-06-24" @default.
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• W2072000132 date "2014-07-15" @default.
• W2072000132 modified "2023-10-16" @default.
• W2072000132 title "Gastroprotective activity of polyphenolic-rich extract of<i>Potentilla mooniana</i>" @default.
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• W2072000132 doi "https://doi.org/10.3109/13880209.2014.905794" @default.
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