Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072007441> ?p ?o ?g. }
- W2072007441 endingPage "1101" @default.
- W2072007441 startingPage "1089" @default.
- W2072007441 abstract "Abstract Heterotrimeric G proteins are well known for their roles in signal transduction downstream of G protein–coupled receptors (GPCRs), and both Gα subunits and tightly associated Gβγ subunits regulate downstream effector molecules. Compared to Gα subunits, the physiological roles of individual Gβ and Gγ subunits are poorly understood. In this study, we generated mice deficient in the Gβ1 gene and found that Gβ1 is required for neural tube closure, neural progenitor cell proliferation, and neonatal development. About 40% Gβ1 −/− embryos developed neural tube defects (NTDs) and abnormal actin organization was observed in the basal side of neuroepithelium. In addition, Gβ1 −/− embryos without NTDs showed microencephaly and died within 2 days after birth. GPCR agonist‐induced ERK phosphorylation, cell proliferation, and cell spreading, which were all found to be regulated by Gαi and Gβγ signaling, were abnormal in Gβ1 −/− neural progenitor cells. These data indicate that Gβ1 is required for normal embryonic neurogenesis. Developmental Dynamics 239:1089–1101, 2010. © 2010 Wiley‐Liss, Inc." @default.
- W2072007441 created "2016-06-24" @default.
- W2072007441 creator A5074919264 @default.
- W2072007441 creator A5082684607 @default.
- W2072007441 date "2010-03-16" @default.
- W2072007441 modified "2023-10-16" @default.
- W2072007441 title "Neural tube defects and impaired neural progenitor cell proliferation in Gβ1-deficient mice" @default.
- W2072007441 cites W1538879480 @default.
- W2072007441 cites W1761319647 @default.
- W2072007441 cites W1862089070 @default.
- W2072007441 cites W1966697925 @default.
- W2072007441 cites W1968320363 @default.
- W2072007441 cites W1972504544 @default.
- W2072007441 cites W1988976106 @default.
- W2072007441 cites W1989915081 @default.
- W2072007441 cites W1991923928 @default.
- W2072007441 cites W2003067279 @default.
- W2072007441 cites W2009370123 @default.
- W2072007441 cites W2012006264 @default.
- W2072007441 cites W2012759193 @default.
- W2072007441 cites W2017810117 @default.
- W2072007441 cites W2022431906 @default.
- W2072007441 cites W2025837534 @default.
- W2072007441 cites W2026776024 @default.
- W2072007441 cites W2027182286 @default.
- W2072007441 cites W2032179686 @default.
- W2072007441 cites W2035079756 @default.
- W2072007441 cites W2044775506 @default.
- W2072007441 cites W2055886980 @default.
- W2072007441 cites W2060118972 @default.
- W2072007441 cites W2065631407 @default.
- W2072007441 cites W2068592712 @default.
- W2072007441 cites W2079001140 @default.
- W2072007441 cites W2083612980 @default.
- W2072007441 cites W2084277378 @default.
- W2072007441 cites W2086545085 @default.
- W2072007441 cites W2089193522 @default.
- W2072007441 cites W2097448914 @default.
- W2072007441 cites W2097899984 @default.
- W2072007441 cites W2098509726 @default.
- W2072007441 cites W2099380050 @default.
- W2072007441 cites W2119930934 @default.
- W2072007441 cites W2125563801 @default.
- W2072007441 cites W2138058987 @default.
- W2072007441 cites W2141695116 @default.
- W2072007441 cites W2143068056 @default.
- W2072007441 cites W2143141083 @default.
- W2072007441 cites W2147020822 @default.
- W2072007441 cites W2150521647 @default.
- W2072007441 cites W2151777177 @default.
- W2072007441 cites W2155798611 @default.
- W2072007441 cites W2156428890 @default.
- W2072007441 cites W2162507709 @default.
- W2072007441 cites W2162676753 @default.
- W2072007441 cites W2170636321 @default.
- W2072007441 cites W2413018742 @default.
- W2072007441 doi "https://doi.org/10.1002/dvdy.22256" @default.
- W2072007441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20186915" @default.
- W2072007441 hasPublicationYear "2010" @default.
- W2072007441 type Work @default.
- W2072007441 sameAs 2072007441 @default.
- W2072007441 citedByCount "53" @default.
- W2072007441 countsByYear W20720074412012 @default.
- W2072007441 countsByYear W20720074412013 @default.
- W2072007441 countsByYear W20720074412014 @default.
- W2072007441 countsByYear W20720074412015 @default.
- W2072007441 countsByYear W20720074412016 @default.
- W2072007441 countsByYear W20720074412017 @default.
- W2072007441 countsByYear W20720074412018 @default.
- W2072007441 countsByYear W20720074412019 @default.
- W2072007441 countsByYear W20720074412020 @default.
- W2072007441 countsByYear W20720074412021 @default.
- W2072007441 countsByYear W20720074412022 @default.
- W2072007441 countsByYear W20720074412023 @default.
- W2072007441 crossrefType "journal-article" @default.
- W2072007441 hasAuthorship W2072007441A5074919264 @default.
- W2072007441 hasAuthorship W2072007441A5082684607 @default.
- W2072007441 hasBestOaLocation W20720074411 @default.
- W2072007441 hasConcept C104317684 @default.
- W2072007441 hasConcept C135285700 @default.
- W2072007441 hasConcept C136834591 @default.
- W2072007441 hasConcept C139407321 @default.
- W2072007441 hasConcept C145103041 @default.
- W2072007441 hasConcept C196843134 @default.
- W2072007441 hasConcept C200707615 @default.
- W2072007441 hasConcept C201750760 @default.
- W2072007441 hasConcept C2780594696 @default.
- W2072007441 hasConcept C28328180 @default.
- W2072007441 hasConcept C461258 @default.
- W2072007441 hasConcept C4746552 @default.
- W2072007441 hasConcept C54355233 @default.
- W2072007441 hasConcept C62112901 @default.
- W2072007441 hasConcept C62478195 @default.
- W2072007441 hasConcept C80631254 @default.
- W2072007441 hasConcept C86803240 @default.
- W2072007441 hasConcept C95444343 @default.
- W2072007441 hasConceptScore W2072007441C104317684 @default.
- W2072007441 hasConceptScore W2072007441C135285700 @default.