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- W2072007776 abstract "UV-induced DNA damage causes repression of RNA synthesis. Following the removal of DNA lesions, transcription recovery operates through a process that is not understood yet. Here we show that knocking-out of the histone methyltransferase DOT1L in mouse embryonic fibroblasts (MEF(DOT1L)) leads to a UV hypersensitivity coupled to a deficient recovery of transcription initiation after UV irradiation. However, DOT1L is not implicated in the removal of the UV-induced DNA damage by the nucleotide excision repair pathway. Using FRAP and ChIP experiments we established that DOT1L promotes the formation of the pre-initiation complex on the promoters of UV-repressed genes and the appearance of transcriptionally active chromatin marks. Treatment with Trichostatin A, relaxing chromatin, recovers both transcription initiation and UV-survival. Our data suggest that DOT1L secures an open chromatin structure in order to reactivate RNA Pol II transcription initiation after a genotoxic attack." @default.
- W2072007776 created "2016-06-24" @default.
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- W2072007776 date "2013-07-04" @default.
- W2072007776 modified "2023-10-16" @default.
- W2072007776 title "Histone Methyltransferase DOT1L Drives Recovery of Gene Expression after a Genotoxic Attack" @default.
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- W2072007776 doi "https://doi.org/10.1371/journal.pgen.1003611" @default.
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