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• W2072010015 abstract "Concentration of hydrogen ions is an important regulator of cerebral arterial tone under physiological and pathological conditions. Previous studies demonstrated that in cerebral arteries, relaxations to hypercapnia are due to decrease in extracellular pH. The present study was designed to determine the role of potassium channels in mediation of cerebral arterial relaxations induced by extracellular acidosis.Rings of canine basilar arteries without endothelium were suspended for isometric force recording. Acidosis (pH 7.3 to 7.0) was produced by incremental addition of hydrochloric acid (1.0N). The concentration of hydrogen ions was continuously monitored with a pH meter.During contractions to UTP, acidosis (pH 7.3 to 7.0) induced pH-dependent relaxations. These relaxations were abolished in arteries contracted by potassium chloride (20 mmol/L). A nonselective potassium channel inhibitor, BaCl2 (10(-4) and 10(-4) mol/L), and an ATP-sensitive potassium channel inhibitor, glyburide (5 x 10(-6) mol/L), significantly reduced relaxations to acidosis. Furthermore, BaCl2 (10(-4) mol/L) and glyburide (5 x 10(-6) mol/L) abolished relaxations to an ATP-sensitive potassium channel opener, cromakalim (10(-8) to 3 x 10(-5) mol/L). However, these potassium channel inhibitors did not affect relaxations to a voltage-dependent calcium channel inhibitor, diltiazem (10(-8) to 10(-4) mol/L), and glyburide (5 x 10(-6) mol/L) did not alter relaxations to a nitric oxide donor, SIN-1 (10(-9) to 10(-4) mol/L). A calcium-activated potassium channel inhibitor, charybdotoxin (10(-7) mol/L), and a delayed rectifier potassium channel inhibitor, 4-aminopyridine (10(-3) mol/L), did not affect relaxations to acidosis.These results suggest that extracellular acidosis causes relaxations of cerebral arteries in part by activation of potassium channels. ATP-sensitive potassium channels appear to contribute to acidosis-induced decrease in cerebral arterial tone." @default.
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• W2072010015 date "1997-02-01" @default.
• W2072010015 modified "2023-10-15" @default.
• W2072010015 title "Role of Potassium Channels in Relaxations of Isolated Canine Basilar Arteries to Acidosis" @default.
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• W2072010015 doi "https://doi.org/10.1161/01.str.28.2.433" @default.
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