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- W2072010040 abstract "The anti-CD3 monoclonal antibody OKT3 has been used as induction therapy in renal transplantation for more than a decade. As compared with patients receiving cyclosporine (Sandimmune, Novartis Pharma, Basel, Switzerland) and azathioprine, patients receiving OKT3 had a lower incidence of rejection and improved long-term graft survival. The advantage of OKT3 induction for survival was apparent only if induction lasted for at least a week and if the administration of cyclosporine was delayed for several days. Patients at higher immunologic risk showed the greatest improvement in graft survival. OKT3 and antithymocyte globulin induction still helps to reduce rejection rates in patients receiving cyclosporine (Neoral, Novartis Pharm.), tacrolimus, or mycophenolate mofetil. OKT3 is, however, a first-generation monoclonal antibody, which may lead to cytokine release, complement activation, sensitization, and overimmunosuppression. This experience has helped to set the standards for the production of new monoclonal antibodies in transplantation." @default.
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- W2072010040 date "1999-12-01" @default.
- W2072010040 modified "2023-09-26" @default.
- W2072010040 title "Induction with anti-CD3 antibodies" @default.
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