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- W2072012406 abstract "The T cell-secreted lymphokine interleukin 13 (IL-13) exerts pleiotropic effects on monocytes (Mφ) and B cells. Since accessory cells, like Mφ and B cells, also act in antigen-presenting and lymphokine augmentation of T cells, Mφ and B cells may be able to effect T cell IL-13 production. Purified T cells produced slightly less IL-13 than the lower T cell numbers contained in peripheral blood mononuclear cell population, further suggesting accessory cell augmentation. Addition of 10% B cells [either unstimulated or pokeweed mitogen (PWM)-stimulated] to autologous T cells only moderately augmented T cell IL-13 levels. PWM-stimulated B cell culture supernates had even less augmenting effect on T cell IL-13 levels and unstimulated B cell culture supernates did not augment T cell IL-13 production. In contrast to the moderately augmenting effect of B cells or their stimulated culture supernates, addition of 10% Mφ, either unstimulated or muramyl dipeptide (MDP)+IFN-γ stimulated, to autologous T cells produced a highly significant increase in T cell IL-13 production. Mφ culture supernates were equally effective in augmenting T cell IL-13 levels, suggesting both that cell-to-cell contact is not critical for Mφ augmentation of T cell IL-13 levels, and that Mφ secreted factors are pivotal. CD64+Mφ (or their culture supernates), which are known as poor antigen-presenting cells, also effectively augmented T cell IL-13 production, further supporting the involvement of Mφ secreted factors. Finally, experiments with exogenous addition of recombinant monokines, as well as neutralization experiments with different cytokine antibodies, suggested IL-1β as a primary cytokine involved in the augmentation of T cell IL-13 levels by accessory cells. However, these experiments also indicated other unidentified Mφ factors as playing a significant role in producing maximal T cell IL-13 production." @default.
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- W2072012406 date "1998-12-01" @default.
- W2072012406 modified "2023-10-03" @default.
- W2072012406 title "MAXIMAL T CELL IL-13 PRODUCTION REQUIRES MONOCYTE OR MONOKINE PARTICIPATION" @default.
- W2072012406 doi "https://doi.org/10.1006/cyto.1998.0380" @default.
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