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- W2072017567 abstract "ABSTRACTElectromobility-shift assay (EMSA) was applied for studying the competition between the anticancer antibiotic actinomycin D (ACTD) and linker histones H1 and H5 for binding to DNA. ACTD is widely used in the treatment of some malignancies. Its binding to DNA occurs in two steps: initial intercalation between guanine and cytosine bases followed by invading the minor groove of the polynucleotide chain. As a consequence of this structural perturbation of DNA, a strong interference with the binding of important regulatory and functional proteins to DNA may occur. Here we present our recent experimental data obtained in a drug-competition assay between ACTD and linker histones H1 and H5 under the following conditions: i) simultaneous incubation of DNA with the antibiotic and histone; ii) preincubation of DNA with ACTD and subsequent addition of the histone; and iii) preincubation of DNA with histone and subsequent addition of the drug. Surprisingly, linker histones bound more effectively to ACTD-pretre..." @default.
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- W2072017567 date "2009-01-01" @default.
- W2072017567 modified "2023-09-24" @default.
- W2072017567 title "Highly Preferential Linker Histone Binding to Actinomycin D-Treated DNA" @default.
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- W2072017567 doi "https://doi.org/10.1080/13102818.2009.10817610" @default.
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