Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072020101> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2072020101 endingPage "33" @default.
- W2072020101 startingPage "24" @default.
- W2072020101 abstract "Soyasaponins are bioactive compounds found in many legumes. Although crude soyasaponins have been shown to have anti-colon carcinogenic activity, there have been no structure-activity studies. In this study, therefore, purified soyasaponins and soyasapogenins were tested for their ability to suppress the growth of HT-29 colon cancer cells, as determined by the WST-1 assay, over a concentration range of 0-50 ppm. Soyasaponin I and III, soyasapogenol B monoglucuronide, soyasapogenol B, soyasaponin A1, soyasaponin A2, and soyasapogenol A were evaluated. Also tested were mixtures comprising acetylated group A soyasaponins, deacetylated group A soyasaponins, and group B soyasaponins. The most potent compounds were the aglycones soyasapogenol A and B, which showed almost complete suppression of cell growth. The glycosidic soyasaponins by comparison were largely inactive. Soyasaponin A(1), A(2), and I, group B and deacetylated and acetylated group A fractions had no effect on cell growth. Soyasaponin III and soyasapogenol B monoglucuronide were marginally bioactive. These results suggested that the bioactivity of soyasaponins increased with increased lipophilicity. Results from in vitro fermentation suggested that colonic microflora readily hydrolyzed the soyasaponins to aglycones. These observations suggest that the soyasaponins may be an important dietary chemopreventive agent against colon cancer, after alteration by microflora." @default.
- W2072020101 created "2016-06-24" @default.
- W2072020101 creator A5032699619 @default.
- W2072020101 creator A5043915046 @default.
- W2072020101 date "2003-09-01" @default.
- W2072020101 modified "2023-10-14" @default.
- W2072020101 title "Soyasaponins: The Relationship Between Chemical Structure and Colon Anticarcinogenic Activity" @default.
- W2072020101 cites W1497913672 @default.
- W2072020101 cites W1509946697 @default.
- W2072020101 cites W1533091445 @default.
- W2072020101 cites W1764658750 @default.
- W2072020101 cites W1966758367 @default.
- W2072020101 cites W1971564688 @default.
- W2072020101 cites W1972173910 @default.
- W2072020101 cites W1977798786 @default.
- W2072020101 cites W1978009883 @default.
- W2072020101 cites W1992017511 @default.
- W2072020101 cites W1998952770 @default.
- W2072020101 cites W2000526947 @default.
- W2072020101 cites W2002275634 @default.
- W2072020101 cites W2003524423 @default.
- W2072020101 cites W2003697881 @default.
- W2072020101 cites W2004029402 @default.
- W2072020101 cites W2005261841 @default.
- W2072020101 cites W2005598640 @default.
- W2072020101 cites W2011215016 @default.
- W2072020101 cites W2014148466 @default.
- W2072020101 cites W2018095902 @default.
- W2072020101 cites W2024033053 @default.
- W2072020101 cites W2033164566 @default.
- W2072020101 cites W2040135364 @default.
- W2072020101 cites W2056803762 @default.
- W2072020101 cites W2058893249 @default.
- W2072020101 cites W2072724886 @default.
- W2072020101 cites W2079336016 @default.
- W2072020101 cites W2079962399 @default.
- W2072020101 cites W2091205460 @default.
- W2072020101 cites W2091840671 @default.
- W2072020101 cites W2135437454 @default.
- W2072020101 cites W2243000210 @default.
- W2072020101 cites W2315537951 @default.
- W2072020101 cites W2328078985 @default.
- W2072020101 cites W4239867965 @default.
- W2072020101 cites W4244328299 @default.
- W2072020101 cites W73249300 @default.
- W2072020101 doi "https://doi.org/10.1207/s15327914nc4701_3" @default.
- W2072020101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14769534" @default.
- W2072020101 hasPublicationYear "2003" @default.
- W2072020101 type Work @default.
- W2072020101 sameAs 2072020101 @default.
- W2072020101 citedByCount "140" @default.
- W2072020101 countsByYear W20720201012012 @default.
- W2072020101 countsByYear W20720201012013 @default.
- W2072020101 countsByYear W20720201012014 @default.
- W2072020101 countsByYear W20720201012015 @default.
- W2072020101 countsByYear W20720201012016 @default.
- W2072020101 countsByYear W20720201012017 @default.
- W2072020101 countsByYear W20720201012018 @default.
- W2072020101 countsByYear W20720201012019 @default.
- W2072020101 countsByYear W20720201012020 @default.
- W2072020101 countsByYear W20720201012021 @default.
- W2072020101 countsByYear W20720201012022 @default.
- W2072020101 countsByYear W20720201012023 @default.
- W2072020101 crossrefType "journal-article" @default.
- W2072020101 hasAuthorship W2072020101A5032699619 @default.
- W2072020101 hasAuthorship W2072020101A5043915046 @default.
- W2072020101 hasConcept C185592680 @default.
- W2072020101 hasConcept C194671627 @default.
- W2072020101 hasConcept C201399114 @default.
- W2072020101 hasConcept C55493867 @default.
- W2072020101 hasConcept C71240020 @default.
- W2072020101 hasConceptScore W2072020101C185592680 @default.
- W2072020101 hasConceptScore W2072020101C194671627 @default.
- W2072020101 hasConceptScore W2072020101C201399114 @default.
- W2072020101 hasConceptScore W2072020101C55493867 @default.
- W2072020101 hasConceptScore W2072020101C71240020 @default.
- W2072020101 hasIssue "1" @default.
- W2072020101 hasLocation W20720201011 @default.
- W2072020101 hasLocation W20720201012 @default.
- W2072020101 hasOpenAccess W2072020101 @default.
- W2072020101 hasPrimaryLocation W20720201011 @default.
- W2072020101 hasRelatedWork W1531601525 @default.
- W2072020101 hasRelatedWork W2319480705 @default.
- W2072020101 hasRelatedWork W2384464875 @default.
- W2072020101 hasRelatedWork W2606230654 @default.
- W2072020101 hasRelatedWork W2607424097 @default.
- W2072020101 hasRelatedWork W2748952813 @default.
- W2072020101 hasRelatedWork W2899084033 @default.
- W2072020101 hasRelatedWork W2948807893 @default.
- W2072020101 hasRelatedWork W4387497383 @default.
- W2072020101 hasRelatedWork W2778153218 @default.
- W2072020101 hasVolume "47" @default.
- W2072020101 isParatext "false" @default.
- W2072020101 isRetracted "false" @default.
- W2072020101 magId "2072020101" @default.
- W2072020101 workType "article" @default.