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- W2072021160 abstract "The severity of gingivitis in relation to abnormal macrophage chemotaxis and Superoxide (O2−) production was investigated in rats with naturally occurring gingivitis (plaque-susceptible rats). Macrophage chemotaxis was measured by the membrane filter method; zymosan-activated serum was used as a chemo-attractant. O2− production was measured by the reduction of cytochrome c method. Opsonized zymosan, phorbol myristate acetate and calcium ionophore A23187 were used as stimulants. The macrophage chemotaxis and O2− production in the plaque-susceptible rats with deep pockets were significantly lower than those in the susceptible rats with shallow pockets or the normal group. In addition, there was a negative correlation between the severity of gingivitis in plaque-susceptible rats and macrophage chemotaxis or O2− production. These findings suggest that impairement of the host defence mechanisms due to the reduction in macrophage chemotaxis and O2− production is related to the progression of periodontal disease in plaque-susceptible rats." @default.
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- W2072021160 date "1990-01-01" @default.
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- W2072021160 title "Leucocyte function in rats with naturally occurring gingivitis" @default.
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- W2072021160 doi "https://doi.org/10.1016/0003-9969(90)90154-3" @default.
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