Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072023765> ?p ?o ?g. }
- W2072023765 endingPage "348" @default.
- W2072023765 startingPage "333" @default.
- W2072023765 abstract "Brain biopsy specimens from five patients with Alzheimer's disease obtained in the course of a trial of intracerebroventricular bethanechol were studied by immunohistochemical (antibody to A4 peptide) and ultrastructural techniques, with particular emphasis on the microvessels. In some cases, numbers of A4-immunoreactive lesions (senile plaques) correlated well with numbers of plaques demonstrable by silver stains. Prominent A4-immunoreactive amyloid angiopathy was seen in one patient. The patient with severe cerebral amyloid angiopathy (CAA) showed extensive arteriolar deposition of amyloid filaments with apparent destruction of the media but remarkably intact endothelium. A cell of origin for amyloid filaments was not apparent, although close proximity to smooth muscle cell remnants in the arteriolar media suggested this as one possible cell of origin. Frequent vessels showed medial or adventitial collagen deposition, even when the amount of amyloid was minimal or negligible. Thus relatively severe CAA can exist in the absence of overt endothelial injury, although related studies on this tissue indicate definite abnormalities of the blood-brain barrier. Conversely, destruction of smooth muscle cells and collagen deposition in vessel walls may be the cellular correlates of arteriolar weakening that can lead to CAA-related brain hemorrhage." @default.
- W2072023765 created "2016-06-24" @default.
- W2072023765 creator A5001402022 @default.
- W2072023765 creator A5029293968 @default.
- W2072023765 creator A5029764702 @default.
- W2072023765 creator A5040650353 @default.
- W2072023765 creator A5054925181 @default.
- W2072023765 creator A5068914336 @default.
- W2072023765 creator A5070097276 @default.
- W2072023765 creator A5088544093 @default.
- W2072023765 date "1994-01-01" @default.
- W2072023765 modified "2023-10-13" @default.
- W2072023765 title "Microvasculature in Brain Biopsy Specimens from Patients with Alzheimer's Disease: An Immunohistochemical and Ultrastructural Study" @default.
- W2072023765 cites W1515586143 @default.
- W2072023765 cites W1968769088 @default.
- W2072023765 cites W1970999274 @default.
- W2072023765 cites W1977716945 @default.
- W2072023765 cites W1981063463 @default.
- W2072023765 cites W1982412295 @default.
- W2072023765 cites W1987046654 @default.
- W2072023765 cites W1988056924 @default.
- W2072023765 cites W1988211686 @default.
- W2072023765 cites W1991880215 @default.
- W2072023765 cites W1992176243 @default.
- W2072023765 cites W1999191250 @default.
- W2072023765 cites W2000999053 @default.
- W2072023765 cites W2008510386 @default.
- W2072023765 cites W2008602320 @default.
- W2072023765 cites W2009459205 @default.
- W2072023765 cites W2015675204 @default.
- W2072023765 cites W2016412244 @default.
- W2072023765 cites W2024175982 @default.
- W2072023765 cites W2025313184 @default.
- W2072023765 cites W2026877322 @default.
- W2072023765 cites W2030664361 @default.
- W2072023765 cites W2032920422 @default.
- W2072023765 cites W2040625258 @default.
- W2072023765 cites W2041904123 @default.
- W2072023765 cites W2042331487 @default.
- W2072023765 cites W2043093287 @default.
- W2072023765 cites W2045966187 @default.
- W2072023765 cites W2046847750 @default.
- W2072023765 cites W2047403340 @default.
- W2072023765 cites W2054659083 @default.
- W2072023765 cites W2055005795 @default.
- W2072023765 cites W2057505475 @default.
- W2072023765 cites W2059457068 @default.
- W2072023765 cites W2059640473 @default.
- W2072023765 cites W2059765329 @default.
- W2072023765 cites W2061441248 @default.
- W2072023765 cites W2066523545 @default.
- W2072023765 cites W2067197608 @default.
- W2072023765 cites W2074364608 @default.
- W2072023765 cites W2075610076 @default.
- W2072023765 cites W2076272666 @default.
- W2072023765 cites W2079430002 @default.
- W2072023765 cites W2079953735 @default.
- W2072023765 cites W2089418640 @default.
- W2072023765 cites W2091985395 @default.
- W2072023765 cites W2097834079 @default.
- W2072023765 cites W2104927178 @default.
- W2072023765 cites W2109572934 @default.
- W2072023765 cites W2134941195 @default.
- W2072023765 cites W2138635973 @default.
- W2072023765 cites W2144960693 @default.
- W2072023765 cites W2171405125 @default.
- W2072023765 cites W2885401802 @default.
- W2072023765 doi "https://doi.org/10.3109/01913129409023202" @default.
- W2072023765 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8066824" @default.
- W2072023765 hasPublicationYear "1994" @default.
- W2072023765 type Work @default.
- W2072023765 sameAs 2072023765 @default.
- W2072023765 citedByCount "120" @default.
- W2072023765 countsByYear W20720237652012 @default.
- W2072023765 countsByYear W20720237652013 @default.
- W2072023765 countsByYear W20720237652014 @default.
- W2072023765 countsByYear W20720237652015 @default.
- W2072023765 countsByYear W20720237652016 @default.
- W2072023765 countsByYear W20720237652018 @default.
- W2072023765 countsByYear W20720237652019 @default.
- W2072023765 countsByYear W20720237652020 @default.
- W2072023765 countsByYear W20720237652021 @default.
- W2072023765 countsByYear W20720237652022 @default.
- W2072023765 countsByYear W20720237652023 @default.
- W2072023765 crossrefType "journal-article" @default.
- W2072023765 hasAuthorship W2072023765A5001402022 @default.
- W2072023765 hasAuthorship W2072023765A5029293968 @default.
- W2072023765 hasAuthorship W2072023765A5029764702 @default.
- W2072023765 hasAuthorship W2072023765A5040650353 @default.
- W2072023765 hasAuthorship W2072023765A5054925181 @default.
- W2072023765 hasAuthorship W2072023765A5068914336 @default.
- W2072023765 hasAuthorship W2072023765A5070097276 @default.
- W2072023765 hasAuthorship W2072023765A5088544093 @default.
- W2072023765 hasConcept C126322002 @default.
- W2072023765 hasConcept C134018914 @default.
- W2072023765 hasConcept C142724271 @default.
- W2072023765 hasConcept C204232928 @default.
- W2072023765 hasConcept C2775934546 @default.