Matches in SemOpenAlex for { <https://semopenalex.org/work/W2072025687> ?p ?o ?g. }
- W2072025687 endingPage "103" @default.
- W2072025687 startingPage "95" @default.
- W2072025687 abstract "The role of breast cancer resistance protein (BCRP), an efflux ABC transporter, in the pharmacokinetics of substrate drugs in humans is unknown. We investigated the impact of genetic polymorphisms of ABCG2 (421C>A) and NAT2 on the pharmacokinetics of sulfasalazine (SASP), a dual substrate, in 37 healthy volunteers, taking 2,000 mg of conventional SASP tablets. In ABCG2, SASP AUC0–48 of C/C, C/A, and A/A subjects was 171 ± 85, 330 ± 194, and 592 ± 275 μg h/ml, respectively, with significant differences among groups. In contrast, AUC0–48 of sulfapyridine (SP) tended to be lower in subjects with the ABCG2-A allele as homozygosity. In NAT2, AUCAcSP/AUCSP was significantly higher in rapid than in intermediate and slow acetylator (SA) genotypes. We successfully described the pharmacokinetics of SASP, SP, and N -acetylsulfapyridine (AcSP) simultaneously by nonlinear mixed-effects modeling (NONMEM) analysis with regard to both gene polymorphisms. The data indicate that SASP is a candidate probe of BCRP, particularly in its role in intestinal absorption. Clinical Pharmacology & Therapeutics (2008); 84, 1, 95–103 doi:10.1038/sj.clpt.6100459" @default.
- W2072025687 created "2016-06-24" @default.
- W2072025687 creator A5021988031 @default.
- W2072025687 creator A5027984186 @default.
- W2072025687 creator A5034526773 @default.
- W2072025687 creator A5048279225 @default.
- W2072025687 creator A5048577166 @default.
- W2072025687 creator A5054326909 @default.
- W2072025687 creator A5061014418 @default.
- W2072025687 creator A5062272410 @default.
- W2072025687 creator A5070460587 @default.
- W2072025687 creator A5079317300 @default.
- W2072025687 creator A5088648351 @default.
- W2072025687 creator A5091836925 @default.
- W2072025687 date "2008-01-02" @default.
- W2072025687 modified "2023-10-16" @default.
- W2072025687 title "Pharmacogenetic Characterization of Sulfasalazine Disposition Based on NAT2 and ABCG2 (BCRP) Gene Polymorphisms in Humans" @default.
- W2072025687 cites W1497372115 @default.
- W2072025687 cites W1566382259 @default.
- W2072025687 cites W1587924678 @default.
- W2072025687 cites W1972161651 @default.
- W2072025687 cites W1976805469 @default.
- W2072025687 cites W1980180158 @default.
- W2072025687 cites W1981078630 @default.
- W2072025687 cites W1989168778 @default.
- W2072025687 cites W1989737284 @default.
- W2072025687 cites W1999997714 @default.
- W2072025687 cites W2000498456 @default.
- W2072025687 cites W2001257866 @default.
- W2072025687 cites W2009161466 @default.
- W2072025687 cites W2011863437 @default.
- W2072025687 cites W2030606600 @default.
- W2072025687 cites W2032447921 @default.
- W2072025687 cites W2039299577 @default.
- W2072025687 cites W2041715456 @default.
- W2072025687 cites W2048729835 @default.
- W2072025687 cites W2050077474 @default.
- W2072025687 cites W2050381784 @default.
- W2072025687 cites W2050453675 @default.
- W2072025687 cites W2051835394 @default.
- W2072025687 cites W2060000547 @default.
- W2072025687 cites W2060798530 @default.
- W2072025687 cites W2066076563 @default.
- W2072025687 cites W2076174476 @default.
- W2072025687 cites W2095908153 @default.
- W2072025687 cites W2121900915 @default.
- W2072025687 cites W2124768437 @default.
- W2072025687 cites W2133287244 @default.
- W2072025687 cites W2147930289 @default.
- W2072025687 cites W2150323980 @default.
- W2072025687 cites W2153203699 @default.
- W2072025687 cites W2410042695 @default.
- W2072025687 cites W2415775034 @default.
- W2072025687 cites W2438083907 @default.
- W2072025687 cites W4214819428 @default.
- W2072025687 cites W4238330088 @default.
- W2072025687 doi "https://doi.org/10.1038/sj.clpt.6100459" @default.
- W2072025687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18167504" @default.
- W2072025687 hasPublicationYear "2008" @default.
- W2072025687 type Work @default.
- W2072025687 sameAs 2072025687 @default.
- W2072025687 citedByCount "143" @default.
- W2072025687 countsByYear W20720256872012 @default.
- W2072025687 countsByYear W20720256872013 @default.
- W2072025687 countsByYear W20720256872014 @default.
- W2072025687 countsByYear W20720256872015 @default.
- W2072025687 countsByYear W20720256872016 @default.
- W2072025687 countsByYear W20720256872017 @default.
- W2072025687 countsByYear W20720256872018 @default.
- W2072025687 countsByYear W20720256872019 @default.
- W2072025687 countsByYear W20720256872020 @default.
- W2072025687 countsByYear W20720256872021 @default.
- W2072025687 countsByYear W20720256872022 @default.
- W2072025687 countsByYear W20720256872023 @default.
- W2072025687 crossrefType "journal-article" @default.
- W2072025687 hasAuthorship W2072025687A5021988031 @default.
- W2072025687 hasAuthorship W2072025687A5027984186 @default.
- W2072025687 hasAuthorship W2072025687A5034526773 @default.
- W2072025687 hasAuthorship W2072025687A5048279225 @default.
- W2072025687 hasAuthorship W2072025687A5048577166 @default.
- W2072025687 hasAuthorship W2072025687A5054326909 @default.
- W2072025687 hasAuthorship W2072025687A5061014418 @default.
- W2072025687 hasAuthorship W2072025687A5062272410 @default.
- W2072025687 hasAuthorship W2072025687A5070460587 @default.
- W2072025687 hasAuthorship W2072025687A5079317300 @default.
- W2072025687 hasAuthorship W2072025687A5088648351 @default.
- W2072025687 hasAuthorship W2072025687A5091836925 @default.
- W2072025687 hasConcept C104317684 @default.
- W2072025687 hasConcept C112705442 @default.
- W2072025687 hasConcept C126322002 @default.
- W2072025687 hasConcept C135763542 @default.
- W2072025687 hasConcept C149011108 @default.
- W2072025687 hasConcept C178790620 @default.
- W2072025687 hasConcept C185592680 @default.
- W2072025687 hasConcept C2777031107 @default.
- W2072025687 hasConcept C2779134260 @default.
- W2072025687 hasConcept C2779383735 @default.
- W2072025687 hasConcept C2780479503 @default.