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- W2072056597 abstract "<h3>Objective</h3> The purpose of this study was to elucidate the role of ghrelin after acute myocardial infarction (AMI) in left ventricular (LV) remodelling. <h3>Design</h3> Prospective observational study. <h3>Setting</h3> Jichi Medical University Hospital. <h3>Patients</h3> Fifty consecutive patients experiencing their first AMI. <h3>Interventions</h3> Ghrelin was measured on the day of admission, day 7, day 14 and 6 months after AMI. Patients were treated by percutaneous coronary intervention, and successful myocardial reperfusion was accomplished within 12 h after onset. To analyse LV remodelling, the authors performed left ventriculographies on the day of admission and 6 months after AMI. <h3>Main outcome measures</h3> Changes in LV volume. <h3>Results</h3> Plasma ghrelin increased significantly after AMI (admission: 40.9±7.3; day 7: 89.5±11.0; day 14: 92.6±11.8 fmol/ml, p<0.0001). There was a significant correlation between ghrelin on day 14 and changes in LV volume over 6 months (r=+0.46, p<0.001). Multivariate regression analysis showed that ghrelin on day 14 is a significant predictor of LV remodelling after AMI (β=+0.44, p=0.001). <h3>Conclusion</h3> To our knowledge, this is the first report that shows a relation between circulating ghrelin after AMI and the progression of LV remodelling in the chronic phase. The elevation of ghrelin after AMI might be a compensatory mechanism to attenuate LV remodelling." @default.
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- W2072056597 date "2010-01-01" @default.
- W2072056597 modified "2023-09-24" @default.
- W2072056597 title "Roles of ghrelin in left-ventricular remodelling after acute myocardial infarction" @default.
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- W2072056597 doi "https://doi.org/10.1136/ha.2009.000927" @default.
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