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• W2072062890 abstract "ObjectiveCD14 is involved in induction of pro-inflammatory immunity. IL-1ra and hsp70 inhibit pro-inflammatory cytokine expression. We hypothesized that specific combinations of these polymorphic genes may differentially influence the rate of PPROM.Study designBuccal swabs were obtained from 104 mother-twin and three mother-triplet pairs. Cellular DNA was analyzed by polymerase chain reaction for single nucleotide polymorphisms at position – 159 in the CD14 gene, + 1267 in the hsp70 gene and a length polymorphism in intron two of IL-1ra gene. Pregnancy outcome data were obtained after completion of all testing.ResultsPPROM occurred in 28 (26.2%) pregnancies, 11 (39.3%) of which the mother was homozygous for CD14∗T. In contrast, only 13 of 72 (18.1%) pregnancies that did not result in a spontaneous preterm birth (SPTB) were CD14∗T homozygotes (P = .03). There was no relation between the fetal CD14 genotype and PPROM. There was no relation between PPROM and maternal carriage of any IL-1ra or hsp70 genotype. However, PPROM was observed in 32.0% of women homozygous for CD14∗T who were also positive for IL-1ra allele 2 (IL1RN∗2) as opposed to 8.8% of women with no SPTB (P = .009) and 34.8% homozygous for CD14∗T and hsp70∗2 carriage as opposed to 11.1% with no SPTB (P = .01). The specificity for PPROM increased from 81.6% for CD14∗T carriage alone to 88.9% for CD14∗T-hsp70∗T and 91.2% for CD14∗T-IL1RN∗2 carriage.ConclusionIn multifetal pregnancies, maternal homozygous carriage of CD14∗T increases susceptibility to PPROM, especially if associated with carriage of IL1RN∗2 or HSP70∗2. Supported by NIH HD41676. ObjectiveCD14 is involved in induction of pro-inflammatory immunity. IL-1ra and hsp70 inhibit pro-inflammatory cytokine expression. We hypothesized that specific combinations of these polymorphic genes may differentially influence the rate of PPROM. CD14 is involved in induction of pro-inflammatory immunity. IL-1ra and hsp70 inhibit pro-inflammatory cytokine expression. We hypothesized that specific combinations of these polymorphic genes may differentially influence the rate of PPROM. Study designBuccal swabs were obtained from 104 mother-twin and three mother-triplet pairs. Cellular DNA was analyzed by polymerase chain reaction for single nucleotide polymorphisms at position – 159 in the CD14 gene, + 1267 in the hsp70 gene and a length polymorphism in intron two of IL-1ra gene. Pregnancy outcome data were obtained after completion of all testing. Buccal swabs were obtained from 104 mother-twin and three mother-triplet pairs. Cellular DNA was analyzed by polymerase chain reaction for single nucleotide polymorphisms at position – 159 in the CD14 gene, + 1267 in the hsp70 gene and a length polymorphism in intron two of IL-1ra gene. Pregnancy outcome data were obtained after completion of all testing. ResultsPPROM occurred in 28 (26.2%) pregnancies, 11 (39.3%) of which the mother was homozygous for CD14∗T. In contrast, only 13 of 72 (18.1%) pregnancies that did not result in a spontaneous preterm birth (SPTB) were CD14∗T homozygotes (P = .03). There was no relation between the fetal CD14 genotype and PPROM. There was no relation between PPROM and maternal carriage of any IL-1ra or hsp70 genotype. However, PPROM was observed in 32.0% of women homozygous for CD14∗T who were also positive for IL-1ra allele 2 (IL1RN∗2) as opposed to 8.8% of women with no SPTB (P = .009) and 34.8% homozygous for CD14∗T and hsp70∗2 carriage as opposed to 11.1% with no SPTB (P = .01). The specificity for PPROM increased from 81.6% for CD14∗T carriage alone to 88.9% for CD14∗T-hsp70∗T and 91.2% for CD14∗T-IL1RN∗2 carriage. PPROM occurred in 28 (26.2%) pregnancies, 11 (39.3%) of which the mother was homozygous for CD14∗T. In contrast, only 13 of 72 (18.1%) pregnancies that did not result in a spontaneous preterm birth (SPTB) were CD14∗T homozygotes (P = .03). There was no relation between the fetal CD14 genotype and PPROM. There was no relation between PPROM and maternal carriage of any IL-1ra or hsp70 genotype. However, PPROM was observed in 32.0% of women homozygous for CD14∗T who were also positive for IL-1ra allele 2 (IL1RN∗2) as opposed to 8.8% of women with no SPTB (P = .009) and 34.8% homozygous for CD14∗T and hsp70∗2 carriage as opposed to 11.1% with no SPTB (P = .01). The specificity for PPROM increased from 81.6% for CD14∗T carriage alone to 88.9% for CD14∗T-hsp70∗T and 91.2% for CD14∗T-IL1RN∗2 carriage. ConclusionIn multifetal pregnancies, maternal homozygous carriage of CD14∗T increases susceptibility to PPROM, especially if associated with carriage of IL1RN∗2 or HSP70∗2. Supported by NIH HD41676. In multifetal pregnancies, maternal homozygous carriage of CD14∗T increases susceptibility to PPROM, especially if associated with carriage of IL1RN∗2 or HSP70∗2. Supported by NIH HD41676." @default.
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• W2072062890 title "Association of a maternal CD14 gene polymorphism with preterm premature rupture of membranes (PPROM) in multifetal pregnancies and its potentiation by interleukin-1 receptor antagonist (IL-1ra) and 70kDa heat shock protein (hsp70) gene polymorphisms" @default.
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